Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. [PDF]
PLoS ONE, 2008 The Amyloid Precursor Protein (APP) undergoes sequential proteolytic cleavages through the action of beta- and gamma-secretase, which result in the generation of toxic beta-amyloid (Abeta) peptides and a C-terminal fragment consisting of the ...
Garrett G Gross +5 more
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The Nicastrin ectodomain adopts a highly thermostable structure [PDF]
, 2011 Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight gamma-secretase complex. gamma-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the ...
Beyer, Klaus +6 more
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Gamma Secretase Modulators [PDF]
ACS Medicinal Chemistry Letters, 2013 Notes The authors declare no competing financial interest. Title: Gamma Secretase Modulators Application Number: WO 2013066740A1 Publication date: 10 May 2013 Priority Application: 61/553,384 Priority date: 31 October 2011 Inventors: W. Greenlee, D. Pissarnitski, Z. Zhao, Z.
openaire +2 more sources
Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Subunits
Frontiers in Aging Neuroscience, 2015 gamma-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein, catalyzing the formation of amyloid beta peptides that form amyloid plaques, which contribute to Alzheimer’s disease pathogenesis.
Natalya eGertsik +2 more
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Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells. [PDF]
PLoS ONE, 2010 BACKGROUND: The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer's ...
Jesse C Wiley +6 more
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Neurobiology of Disease, 2005 In Alzheimer's disease, the complex catabolism of amyloid precursor protein (APP) leads to the production of amyloid-beta (Abeta) peptide, the major component of amyloid deposits.
Valérie Vingtdeux +12 more
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Gamma-secretase: from pathogenesis to therapeutics [PDF]
Molecular Neurodegeneration, 2012 Background Presenilin (PS) is the catalytic subunit of g-secretase and mutations in this protein cause familial Alzheimer’s Disease (FAD). Moreover, g-secretase has emerged as an appealing drug target for Alzheimer’s disease (AD) and cancer due to its central role in the generation of Ab peptides and the regulation of Notch signaling.
Li Yueming
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Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]
, 2009 Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Dohi, Keiji +27 more
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Gene expression profiling in cells with enhanced gamma-secretase activity.
PLoS ONE, 2009 BackgroundProcessing by gamma-secretase of many type-I membrane protein substrates triggers signaling cascades by releasing intracellular domains (ICDs) that, following nuclear translocation, modulate the transcription of different genes regulating a ...
Alexandra I Magold +2 more
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Epithelial-mesenchymal transition as a potential route for DAPT resistance in breast cancer cells
Türk Biyokimya Dergisi, 2023 Notch is a conserved pathway involved in cell-fate determination and homeostasis. Its dysregulation plays a role in poor prognosis and drug resistance in breast cancer.
Telli Kubra, Yalcin-Ozuysal Ozden
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