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Polymorphs of the antiviral drug ganciclovir
Acta Crystallographica Section C Structural Chemistry, 2017Ganciclovir (GCV; systematic name: 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one), C9H13N5O4, an antiviral drug for treating cytomegalovirus infections, has two known polymorphs (Forms I and II), but only the structure of the metastable Form II has been reported [Kawamura & Hirayama (2009). X-ray Struct. Anal. Online,
Roxana Lili Roque-Flores+3 more
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New England Journal of Medicine, 1996
To the Editor: Several reports of ganciclovir-induced psychiatric disturbances have been reported in the medical literature.1–3 Two cases involved patients with mild renal insufficiency1,2 and one a patient who was undergoing hemodialysis.3 Since ganciclovir is primarily eliminated through the kidney as the parent compound (91 percent),4 renal failure ...
Barbara A. Hansen+2 more
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To the Editor: Several reports of ganciclovir-induced psychiatric disturbances have been reported in the medical literature.1–3 Two cases involved patients with mild renal insufficiency1,2 and one a patient who was undergoing hemodialysis.3 Since ganciclovir is primarily eliminated through the kidney as the parent compound (91 percent),4 renal failure ...
Barbara A. Hansen+2 more
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Japanese Journal of Ophthalmology
To evaluate the pharmacokinetics of ganciclovir eye drops by comparing solutions prepared from ganciclovir for intravenous infusion and ganciclovir gel and to assess the impact of systemic administration on drug levels in ocular tissues and serum.Experimental study design.Ganciclovir solutions (0.5% and 1.0%) prepared by diluting DENOSINE ® IV Infusion
Naoki Okumura+3 more
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To evaluate the pharmacokinetics of ganciclovir eye drops by comparing solutions prepared from ganciclovir for intravenous infusion and ganciclovir gel and to assess the impact of systemic administration on drug levels in ocular tissues and serum.Experimental study design.Ganciclovir solutions (0.5% and 1.0%) prepared by diluting DENOSINE ® IV Infusion
Naoki Okumura+3 more
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Oral Ganciclovir for Cytomegalovirus Infections
1996As of November 1994, there were two medications approved in the USA for the treatment of cytomegalovirus (CMV) retinitis in the immunocompromised patient These are the intravenous formulations of ganciclovir and foscarnet In addition, the intravenous formulation of ganciclovir is approved for the prevention of CMV disease in organ transplant recipients.
Mary Jean Stempien+2 more
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Ganciclovir for Cytomegalovirus Retinitis
Ophthalmology, 2012Jamie B. Rosenberg, Shlomit F. Sandler
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Ganciclovir for intravitreal injection
American Journal of Health-System Pharmacy, 1995Pornanong Aramwit, Richard G. Fiscella
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Ganciclovir-resistant cytomegalovirus
AIDS, 1991John R. Ebright, Lawrence R. Crane
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