Results 81 to 90 of about 28,451 (193)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, Volume 38, Issue 4, Page 220-228, April 2026.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Sono-anatomy of the middle cervical sympathetic ganglion verified with pathology

Heliyon
Objectives: Cervical discomfort and other symptoms may be attributable to the middle cervical sympathetic ganglion. The aim of this study was to explore the sonographic features of this ganglion in anatomical specimens and cadavers and evaluate the ...
Yu-Tao Lei, Yun-Xia Hao, Zhen Yang, Zhuo-Hua Lin, Wen Qin, Jun-Hao Yan, Yang Sun, Li-Gang Cui, Ying Fu   +8 more
doaj   +1 more source

Nationwide Survey of Atopic Myelitis and Plexin D1‐Immunoglobulin G‐Related Pain

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 593-606, March 2026.
ABSTRACT Objective To elucidate the features of plexin D1‐immunoglobulin (Ig)G‐associated neuropathic pain and its relationship to atopic myelitis (AM) in a nationwide Japanese survey. Methods A preliminary survey questionnaire was sent to 1574 selected departments (neurology and pediatrics/pediatric neurology) to explore the numbers of AM and plexin ...
Jun‐ichi Kira, Xu Zhang, Takayuki Fujii, Mikio Mitsuishi, Miho Ushijima, Sato Yoshidomi, Ayako Sakoda, Tomohiro Imamura, Satoshi Kuwabara, Noriko Isobe, Yuri Nakamura   +10 more
wiley   +1 more source

Developmental morphological characteristics of sympathetic ganglia in premature infants

Детские инфекции (Москва)
The results of morphological and clinical-functional studies of the central and peripheral departments of the sympathoadrenal systems of premature newborns are presented. According to the morphometry of deceased newborns, along with pronounced immaturity,
K. V. Dashichev, N. V. Olendar, E. P. Sitnikova, T. L. Uspenskaya, O. V. Kulibina   +4 more
doaj   +1 more source

Tumor‐Infiltrating Nociceptor Neurons in Ovarian Cancer Treatment Resistance

Advanced Biology, Volume 10, Issue 3, March 2026.
This study shows that high‐grade serous ovarian carcinomas (HGSOC) are significantly more innervated than the other histological subtypes. HGSOC small extracellular vesicles (sEVs) promote neurite outgrowth in vitro. Analysis of pre‐ and post‐treatment HGSOC samples shows that innervation increases post‐chemotherapy.
Allison Jorgensen, Daniel W. Vermeer, Euihye Jung, Caitlin S. Williamson, Dalia K. Omran, Lauren E. Schwartz, Ju‐Yoon Yoon, Jeffrey Barr, Ashley L. Tetlow, Camille V. Trinidad, Ronny Drapkin, Andrew K. Godwin, Paola D. Vermeer   +12 more
wiley   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Expert consensus on clinical practice of stellate ganglion block for the treatment of insomnia

Xin yixue
Stellate ganglion block (SGB) is a procedure that involves the injection of local anesthetics into loose connective tissues around the stellate ganglion (SG), which blocks the cervical sympathetic trunk, cervical sympathetic ganglia, and both ...
Guangdong Health Science Popularization Promotion Association Task Force on Clinical Practice of Stellate Ganglion Block for Insomnia Treatment
doaj   +1 more source

Efficacy of Local Bupivacaine Injection of Postoperative Pain in Endoscopic Sinus Surgery

International Forum of Allergy &Rhinology, Volume 16, Issue 3, Page 231-238, March 2026.
ABSTRACT Background Regional anesthesia is effective in alleviating postoperative pain and reducing the requirement for systemic pain medications. However, optimal postoperative pain management in endoscopic sinus surgery (ESS) remains challenging.
Wiracha Leewannapasai, Navarat Tangbumrungtham, Kanokporn Sarsitthithum, Kangsadarn Tanjararak, Boonsam Roongpuvapaht   +4 more
wiley   +1 more source

The spleen–brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Emerging evidence highlights the central role of peripheral immune–metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). Among peripheral organs, the spleen has gained increasing attention as a critical immune–metabolic hub linking systemic homeostasis to central neurodegeneration.
Jingsi Yan, Jiayu Zhang, Xinyi Ye, Huihong Wang, Hang Li, Weirong Li, Huifei Wu, Wei Zhao   +7 more
wiley   +1 more source