Results 141 to 150 of about 355,327 (331)

Genetics‐Based Targeting Strategies for Precise Neuromodulation

open access: yesAdvanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He   +11 more
wiley   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

open access: yesAdvanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang   +4 more
wiley   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

open access: yesAdvanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu   +7 more
wiley   +1 more source

Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease

open access: yesNeurobiology of Disease, 2009
Serotonin has been postulated to play a role in the transplant-induced involuntary movements that occur following intrastriatal grafts of ventral mesencephalic tissue in the treatment of Parkinson's disease.
Emma Louise Lane   +2 more
doaj  

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

open access: yesAdvanced Science, EarlyView.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye   +13 more
wiley   +1 more source

THE ACTION OF CARDIAC GLYCOSIDES ON AUTONOMIC GANGLIA [PDF]

open access: green, 1954
Walter L. Perry, H. Reinert
openalex   +1 more source

Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management

open access: yesAdvanced Science, EarlyView.
Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang   +4 more
wiley   +1 more source

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease

open access: yesNeurobiology of Disease, 2008
The observation that neural grafts can induce dyskinesias has severely hindered the development of a transplantation therapy for Parkinson's disease (PD).
E.L. Lane   +4 more
doaj  

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