Results 51 to 60 of about 238,953 (314)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

The basal ganglia : summary and future modeling research

, 2018
The pivotal idea of the Go-Explore-NoGo (GEN) approach to BG modelling, expounded in this book, is the hypothesis that the complex dynamics of the STN-GPe loop can introduce certain randomness in the action selection mechanisms that occur downstream in ...
V. Srinivasa Chakravarthy, Chakravarthy, Srinivasa, Ahmed A. Moustafa, Moustafa, Ahmed A. (R17078)   +3 more
core   +1 more source

Cerebral activations related to ballistic, stepwise interrupted and gradually modulated movements in parkinson patients [PDF]

, 2012
Patients with Parkinson's disease (PD) experience impaired initiation and inhibition of movements such as difficulty to start/stop walking. At single-joint level this is accompanied by reduced inhibition of antagonist muscle activity.
Gopal Valsan, Bernard A Conway, Leenders Klaus L., Valsan, Gopal, Klaus L Leenders, Maurits, Natasha M.; id_orcid, de Jong, Bauke M.; id_orcid, de Jong, Bauke M., Toxopeus Carolien M., Conway Bernard A., Maurits, Natasha M., Conway, Bernard A., Carolien M Toxopeus, Natasha M Maurits, Maurits Natasha M., Toxopeus, Carolien M., Valsan Gopal, Bauke M de Jong, de Jong Bauke M., Leenders, Klaus L.   +19 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Modulation of Synaptic Amplification in Sympathetic Ganglia [PDF]

, 2013
The purpose of this dissertation was to assess synaptic integration in neurons from the rat superior cervical ganglion (SCG) using complex temporal patterns of virtual synaptic activity that mimic in vivo conditions.
Springer, Mitchell
core  

Sources of the motor and somatic sensory innervation of the trapezius muscle in the rat

Veterinární Medicína, 2010
The study was carried out on nine sexually mature male rats of the Wistar breed weighing approximately 250 g each. Animals were anaesthetized with thiopental sodium injected intraperitoneally (30 mg/kg of body weight). The animals were then injected with
W. Sienkiewicz, A. Dudek
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Satellite cells in developing spinal ganglia. An immunohistochemical study

, 1989
The present immunohistochemical study investigates the presence and distribution of S-100-containing glial cells in the early stages of development in human spinal ganglia.
Domenico Cocchia, Fabrizio Michetti, Lauriola, L, Michetti, F, Coli, A, Bigotti, G, Antonella Coli, Libero Lauriola, Giulio Bigotti   +8 more
core   +1 more source

Pulsed Field Ablation and Neurocardiology: Inert to Efferents or Delayed Destruction?

Reviews in Cardiovascular Medicine
Background: The therapeutic use of irreversible electroporation in clinical cardiac laboratories, termed pulsed field ablation (PFA), is gaining pre-regulatory approval momentum among rhythm specialists for the mitigation of arrhythmogenic substrate ...
Derek Chang, Andrew Arbogast, Ikeotunye Royal Chinyere   +2 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source