Results 41 to 50 of about 355,178 (306)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Danggui Sini decoction protects against oxaliplatin-induced peripheral neuropathy in rats [PDF]

Journal of Integrative Neuroscience, 2020
The effects of Danggui Sini decoction on peripheral neuropathy in oxaliplatin-induced peripheral is established. The results indicated that Danggui Sini decoction treatment significantly reduced the current amplitude of dorsal root ganglia cells ...
Rong Ding, Yue Wang, Ji-Ping Zhu, Wu-Guang Lu, Guo-Li Wei, Zhan-Cheng Gu, Zhen-Tao An, Jie-Ge Huo   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Impulsive-compulsive behaviours and striatal neuroactivity in mildly parkinsonian rats under D2/3 agonist and L-DOPA treatment

npj Parkinson's Disease
Dopamine replacement therapy for Parkinson’s disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining ...
Mirjam Wolfschlag, Elena Espa, Katrine Skovgård, Pär Halje, Maria Angela Cenci   +4 more
doaj   +1 more source

Reduced N‐Type Ca2+ Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Attenuated cardiac vagal activity is associated with ventricular arrhythmogenesis and related mortality in patients with chronic heart failure.
Dongze Zhang, Huiyin Tu, Liang Cao, Hong Zheng, Robert L. Muelleman, Michael C. Wadman, Yu‐Long Li   +6 more
doaj   +1 more source

Voluntary movement takes shape. the link between movement focusing and sensory input gating [PDF]

, 2018
The aim of the study was to investigate the relationship between motor surround inhibition (mSI) and the modulation of somatosensory temporal discrimination threshold (STDT) induced by voluntary movement.
Belvisi, Daniele, Berardelli, Alfredo, Conte, Antonella, Cortese, Francesca Natalia, Li Voti, Pietro, Manzo, Nicoletta, Suppa, Antonio, Tartaglia, Matteo   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Migration and maturation pattern of fetal enteric ganglia: A study of 16 cases

Indian Journal of Pathology and Microbiology, 2011
Aims: To study the migration and developmental pattern of ganglion cells in fetuses aged 9-21 weeks, and to document whether the migration was occurring circumferentially equally in the entire axis or if there were discrepancies in different portions at ...
Ranjana Bandyopadhyay, Uttara Chatterjee, Sanjay K Bandyopadhyay, Ashoke K Basu   +3 more
doaj   +1 more source

The Intrinsic Cardiac Nervous System and Its Role in Cardiac Pacemaking and Conduction

Journal of Cardiovascular Development and Disease, 2020
The cardiac autonomic nervous system (CANS) plays a key role for the regulation of cardiac activity with its dysregulation being involved in various heart diseases, such as cardiac arrhythmias.
Laura Fedele, Thomas Brand
doaj   +1 more source

Is there an integrative center in the vertebrate brain-stem? A robotic evaluation of a model of the reticular formation viewed as an action selection device [PDF]

, 2005
Neurobehavioral data from intact, decerebrate, and neonatal rats, suggests that the reticular formation provides a brainstem substrate for action selection in the vertebrate central nervous system.
Baerends, G., Barto, A., Blumberg, B., Bowsher, D., Cherniak, C., Delwaide, P., Humphries, M., Jones, B., Kevin Gurney, Maes, P., Mark D. Humphries, Montes-Gonzalez, F., Newman, D., Scheibel, M., Stevens, D., Tony J. Prescott   +15 more
core   +2 more sources