Results 91 to 100 of about 137,733 (396)

Risk factors for mortality in fournier's gangrene in a general hospital: use of simplified founier gangrene severe index score (SFGSI)

International Brazilian Journal of Urology, 2018
Objective To evaluate risk factors for mortality in patients with Fournier's gangrene (FG), with emphasis in the Simplified Fournier Gangrene Severe Index Score (SFGSI).
C. Tenório, S. Lima, Amanda V de Albuquerque, Mariana Pauferro Cavalcanti, F. Teles   +4 more
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Análise dos fatores de risco relacionados às amputações maiores e menores de membros inferiores em hospital terciário

Jornal Vascular Brasileiro
Resumo Contexto As amputações dos membros inferiores, sejam definidas como maiores ou menores, são um grave problema de saúde, com altos índices de morbimortalidade e de relevante impacto social. Diferentes características clínicas dos pacientes parecem
Seleno Glauber de Jesus-Silva, João Pedro de Oliveira, Matheus Henrique Colepicolo Brianezi, Melissa Andreia de Moraes Silva, Arturo Eduardo Krupa, Rodolfo Souza Cardoso   +5 more
doaj   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

A curious case of black limb in tuberculosis

Journal of Global Infectious Diseases
With a global burden of 10 million new cases per year, tuberculosis (TB) is a major health problem in developing countries like India, with an incidence of 2.69 million.
Pournami Balasundaran, Heyma Krishna Manoharan, Jitendra Kishore Bhargava, Veerendra Arya, Gowtham Natarajan   +4 more
doaj   +1 more source

Major Amputation Needed to Treat Purulent Tenosynovitis and Necrotizing Fasciitis in a Patient with a Human Bite and Severe COVID-19

International Medical Case Reports Journal, 2022
Akira Toga,1,* Ayush Balaji,2,* Shigeki Nagura1 1Department of Orthopedic Surgery, Saiseikai Yokohama-shi Tobu Hospital, Yokohama, Kanagawa, Japan; 2Hull York Medical School, University of York, York, UK*These authors contributed equally to ...
Toga A, Balaji A, Nagura S
doaj  

Fournier’s Gangrene: Clinical Presentation of 13 Cases

Medical Science Monitor, 2018
Background Fournier’s gangrene (FG) is a fulminant form of infective, polymicrobial, necrotizing fasciitis of the perineal, genital, and perianal regions.
B. Kuzaka, M. Wróblewska, T. Borkowski, D. Kawecki, P. Kuzaka, G. Młynarczyk, P. Radziszewski   +6 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Ileoileal Knotting as a Rare Cause of Acute Small Bowel Obstruction: Report of a Case with Review of Literature

Open Access Surgery, 2023
Telila Mesfin,1 Abdella Degefa,2 Ibsa Kedir Hassen,1 Degefa Gomora,3 Hamza Sultan,2 Kenbon Seyoum,3 Elias Ibrahim,2 Girma Geta,3 Neway Ejigu,3 Sisay Dadi Abebe,4 Teketel Tilahun,5 Demisu Zenbaba,6 Biniyam Sahiledengle,6 Fikreab Desta,6 Getu Kusa Wakoya,1
Mesfin T, Degefa A, Hassen IK, Gomora D, Sultan H, Seyoum K, Ibrahim E, Geta G, Ejigu N, Abebe SD, Tilahun T, Zenbaba D, Sahiledengle B, Desta F, Wakoya GK, Mohamoud SA, Tsegaye M   +16 more
doaj