Results 91 to 100 of about 102,320 (308)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Symmetric Peripheral Gangrene Secondary to Sepsis
Journal of Clinical and Biomedical SciencesSymmetrical peripheral gangrene (SPG) is described as rapid onset of peripheral and symmetrical gangrene in the lack of large vessel occlusive disease with high mortality rate.1 Hereby reporting an event of Upper limb symmetrical gangrene caused
Mohan Reddy K P Mani, S V Srinivasa
doaj +1 more source
Management of Fournier’s gangrene with skin grafting by bagging technique of testes: case report
GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW, 2019 Aim: To share our experience with the management of Fournier gangrene (FG) using the bagging technique of the testes, and to highlight the importance of implementing a multidisciplinary approach in managing FG.
AlShehri, Yasir Ali +3 more
doaj +1 more source
JAMA: The Journal of the American Medical Association, 1896 Gangrene affecting the ear is a very rare disease. It is mentioned in but three out of seven books on the ear, in my library. I have never seen a case in private practice, nor in my service at the various hospitals and dispensaries, until the following one appeared at my clinic at the Illinois Charitable Eye and Ear Infirmary: Jan. 8, 1896, George T.,
openaire +2 more sources
Extensive necrotizing fasciitis from Fournier's gangrene
Urology Case Reports, 2019 Fournier's gangrene is rapidly progressive necrotizing fasciitis that mainly affects the male perineum. Despite the advancement in surgical intervention, Fournier's gangrene carries high rates of mortality.
A. Joury +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Isolated Penile Fournier’s gangrene: A case report and literature review
International journal of surgery case reports, 2019 Highlights • Penile Fournier’s gangrene is very rare clinical entity, which is also known wet gangrene of the penis.• Penile Fournier’s gangrene is reported in only few reports in the literature.• Fournier’s gangrene is usually managed using a multimodal
M. Moussa, Mohamed Abou Chakra
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source