Results 121 to 130 of about 941,776 (219)

GFN1-xTB-Assisted Machine Learning for Electronic Structure Screening of Metal-Organic Frameworks. [PDF]

J Chem Theory Comput
Jose A, Walsh A.
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Correction: Pediatric snakebite in Sub-Saharan Africa: Clinical predictors, outcomes, and gaps in care-A systematic review. [PDF]

PLoS Negl Trop Dis
Mayeden S, Wirth M, Agbaria N, Shaikh MA, Dambach P, Lowery Wilson M, Horstick O, Camacho S, Lang HJ, Deckert A.   +9 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Beyond Pharmacokinetics: Gaps for Rational Use of Medicinal Cannabis. [PDF]

J Clin Pharmacol
Lu S, Liu X, Truong L, Liu Z, Guo F, Martin J, Zhu X.   +6 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Astrovirus infection dysregulates goblet cell-associated antigen passages. [PDF]

iScience
Gulman J, Heredia-Osuna N, Ohanyan M, Poot A, Vargas C, Auerbuch V, McDonald KG, Newberry RD, Cortez V.   +8 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Histological aging signatures for monitoring tissue-specific aging and disease. [PDF]

Nat Med
Abila E, Buljan I, Zheng Y, Kleissl L, Klotz S, Veres T, Weng Z, Nackenhorst M, Kamies R, Michl A, Kadri S, Moustafa S, Hulla W, Perkonigg M, Drach M, Tschandl P, Sterniczky B, Heinig M, De Sadeleer LJ, Wuyts W, Vanaudenaerde B, Ceulemans LJ, Buchanan DD, Fennell LJ, Stary G, Tolkach Y, Wöhrer A, Schiller HB, Rendeiro AF.   +28 more
europepmc   +1 more source