Results 1 to 10 of about 19,010 (211)

Lentinan Alleviated PM2.5 Exposure-Induced Epithelial–Mesenchymal Transition in Pulmonary Epithelial Cells by Inhibiting the GARP/TGF-β/Smad Pathway [PDF]

Toxics
PM2.5 (fine particulate matter) is an air pollutant widely present in urban and industrial areas, which has emerged as a significant threat to human health.
Zhi Wang, Shiqing Xu, Bohao Bian, Zhida Hu, Feiyang Wu, Siqi Zhao, Xiaohui Wang, Li Wang, Teng Ma   +8 more
doaj   +2 more sources

GARP-expressing Tregs as a source of immunosuppressive TGF-β1 in human tumors [PDF]

Cancer Immunology, Immunotherapy
Most cells produce latent transforming growth factor-beta 1 (TGF-β1), but only very few activate the cytokine via cell type-specific mechanisms. TGF-β1 favors cancer progression by suppressing anti-tumor T cell responses.
Pierre Van Meerbeeck, Douae Maatougui, Grégoire de Streel, Noora Vaherto, Etienne Marbaix, Frank Aboubakar Nana, Marc Van den Eynde, Alix Devaux, Javier Carrasco, Agnès Noel, Nicolas van Baren, Sophie Lucas   +11 more
doaj   +2 more sources

Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model [PDF]

Heliyon
Purpose: Radiation therapy (RT) exerts its anti-tumour efficacy by inducing direct damage to cancer cells but also through modification of the tumour microenvironment (TME) by inducing immunogenic antitumor response.
Pierre-Simon Bellaye, Alexandre MM. Dias, Jean-Marc Vrigneaud, Alexanne Bouchard, Mathieu Moreau, Camille Petitot, Claire Bernhard, Michael Claron, Lisa Froidurot, Véronique Morgand, Mélanie Guillemin, Marie Monterrat, Céline Mirjolet, Carmen Garrido, Evelyne Kohli, Bertrand Collin   +15 more
doaj   +2 more sources

GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment

Biology, 2021
Glycoprotein-A repetitions predominant (GARP) is the docking receptor for latent transforming growth factor (LTGF-β) and promotes its activation. In cancer, increased GARP expression has been found in many types of cancer. GARP is expressed by regulatory
Alexanne Bouchard, Bertrand Collin, Carmen Garrido, Pierre-Simon Bellaye, Evelyne Kohli   +4 more
doaj   +1 more source

How Soluble GARP Enhances TGFβ Activation. [PDF]

PLoS ONE, 2016
GARP (glycoprotein A repetitions predominant) is a cell surface receptor on regulatory T-lymphocytes, platelets, hepatic stellate cells and certain cancer cells.
Sven Fridrich, Susanne A Hahn, Marion Linzmaier, Matthias Felten, Jenny Zwarg, Volker Lennerz, Andrea Tuettenberg, Walter Stöcker   +7 more
doaj   +1 more source

GARP Correlates With Tumor-Infiltrating T-Cells and Predicts the Outcome of Gastric Cancer

Frontiers in Immunology, 2021
Accepting the crucial role of the immune microenvironment (TME) in tumor progression enables us to identify immunotherapeutic targets and develop new therapies.
Sutian Jiang, Sutian Jiang, Yifan Zhang, Xiaojing Zhang, Bing Lu, Pingping Sun, Qianqian Wu, Xuzhong Ding, Jianfei Huang, Jianfei Huang   +9 more
doaj   +1 more source

Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity

Journal for ImmunoTherapy of Cancer, 2022
Background Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy. However, most patients with cancer fail to respond clinically. One potential reason is the accumulation of immunosuppressive transforming growth factor β (TGFβ) in the ...
Yi Wang, David Carbone, Zihai Li, Yiping Yang, Kai He, Anqi Li, Qin Ma, Yuzhou Chang, No-Joon Song, Xingjun Wu, Dongjun Chung, Brian P Riesenberg, Maria Velegraki, Giuseppe D Giuliani, Komal Das, Tamio Okimoto, Hyunwoo Kwon, Karthik B Chakravarthy, Chelsea Bolyard, Jayajit Das, Daniel T Gewirth   +20 more
doaj   +1 more source

The role of platelet and endothelial GARP in thrombosis and hemostasis. [PDF]

PLoS ONE, 2017
Glycoprotein-A Repetitions Predominant protein (GARP or LRRC32) is present on among others human platelets and endothelial cells. Evidence for its involvement in thrombus formation was suggested by full knockout of GARP in zebrafish.To evaluate the role ...
Elien Vermeersch, Frederik Denorme, Wim Maes, Simon F De Meyer, Karen Vanhoorelbeke, Justin Edwards, Ethan M Shevach, Derya Unutmaz, Hodaka Fujii, Hans Deckmyn, Claudia Tersteeg   +10 more
doaj   +1 more source

GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins

Frontiers in Cell and Developmental Biology, 2022
Golgi-associated retrograde protein (GARP) is an evolutionary conserved heterotetrameric protein complex that tethers endosome-derived vesicles and is vital for Golgi glycosylation. Microscopy and proteomic approaches were employed to investigate defects
Amrita Khakurel, Tetyana Kudlyk, Irina Pokrovskaya, Zinia D’Souza, Vladimir V. Lupashin   +4 more
doaj   +1 more source

Effect of GARP on osteogenic differentiation of bone marrow mesenchymal stem cells via the regulation of TGFβ1 in vitro [PDF]

PeerJ, 2019
Mesenchymal stem cells (MSCs), which have multipotential differentiation and self-renewal potential, are possible cells for tissue engineering. Transforming growth factor β1 (TGFβ1) can be produced by MSCs in an inactive form, and the activation of TGFβ1
Ruixue Li, Jian Sun, Fei Yang, Yang Sun, Xingwen Wu, Qianrong Zhou, Youcheng Yu, Wei Bi   +7 more
doaj   +2 more sources