Results 81 to 90 of about 145,241 (196)

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

open access: yesAdvanced Science, Volume 12, Issue 20, May 29, 2025.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian   +10 more
wiley   +1 more source

The GhWL1‐GhH1‐GhGA2OX1 Transcriptional Module Regulates Cotton Leaf Morphology

open access: yesAdvanced Science, Volume 12, Issue 20, May 29, 2025.
This study identified GhWL1 as a key gene involved in regulating leaf development through analysis of a T‐DNA insertion mutant. The GhWL1‐GhH1 complex is shown to positively regulate GhGA2OX1 by directly binding to its promoter, thereby establishing the GhWL1‐GhH1‐GhGA2OX1 module as a critical pathway in leaf development.
Jingjing Zhan   +12 more
wiley   +1 more source

GLS1‐Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β‐Catenin Pathway

open access: yesAdvanced Science, EarlyView.
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou   +18 more
wiley   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

open access: yesAdvanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan   +16 more
wiley   +1 more source

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