Results 231 to 240 of about 3,607 (251)

Coral gasdermin triggers pyroptosis

Science Immunology, 2020
Coral gasdermin is activated by caspase 3 and involved in pathogen-induced coral death.
Shuai Jiang, Zhi Zhou, Yuanyuan Sun, Tengfei Zhang, Li Sun   +4 more
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Association between Gasdermin A, Gasdermin B Polymorphisms and Allergic Rhinitis Amongst Jordanians

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2021
Background: Gasdermin A (GSDMA) and Gasdermin B (GSDMB) have been associated with childhood and to a lesser extent with adult asthma in many populations. In this study, we investigate whether there is an association between GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C) at locus 17q21.2 and risk of Allergic Rhinitis among Jordanians. Also, we aimed
Malek Zihlif, Tareq Mahafza, Tawfiq Froukh, Fatima M. AL-Akhras, Rami Alsalman, Margaret Zuriekat, Randa Naffa   +6 more
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Gasdermin and Gasdermin-Like Pore-Forming Proteins in Invertebrates, Fungi and Bacteria

Journal of Molecular Biology, 2022
The gasdermin family of pore-forming proteins (PFPs) has recently emerged as key molecular players controlling immune-related cell death in mammals. Characterized mammalian gasdermins are activated through proteolytic cleavage by caspases or serine proteases, which remove an inhibitory carboxy-terminal domain, allowing the pore-formation process ...
Asen, Daskalov, N Louise, Glass
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Determination of Gasdermin Pores

2023
The gasdermin family represents a type of membrane pore-forming proteins. The gasdermin family is extensively characterized as the executioner of pyroptotic cell death in mammals; recent studies suggest that gasdermin-like pore-forming proteins are also present in bacteria and fungi.
Kun, Wang, Jingjin, Ding, Feng, Shao
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Gasdermins and pyroptosis in the kidney

Nature Reviews Nephrology, 2023
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
Esteban E. Elias, Brayden Lyons, Daniel A. Muruve   +2 more
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Epigenetic and transcriptional control of gasdermins

Seminars in Immunology, 2023
Cells undergo an inflammatory programmed lytic cell death called 'pyroptosis' (with the Greek roots 'fiery'), often featuring morphological hallmarks such as large ballooning protrusions and subsequent bursting. Originally described as a caspase-1-dependent cell death in response to bacterial infection, pyroptosis has since been re-defined in 2018 as a
Cristhian Cadena, Opher S. Kornfeld, Bettina L. Lee, Nobuhiko Kayagaki   +3 more
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Mechanisms of Gasdermin Recognition by Proteases

Journal of Molecular Biology, 2022
Members of the gasdermin family contain positively charged N-terminal domains (NTDs) capable of binding phospholipids and assembling membrane pores, and C-terminal domains (CTDs) that bind the NTDs to prevent pore formation in the resting states. The flexible NTD-CTD linker regions of gasdermins are highly variable in length and sequences, which may be
Zhonghua, Liu, Brianna M, Busscher, Marta, Storl-Desmond, Tsan Sam, Xiao   +3 more
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Transcriptional and Epigenetic Regulation of Gasdermins

Journal of Molecular Biology, 2022
Gasdermins (GSDM) are a family of six homologous proteins (GSDMA to E and Pejvakin) in humans. GSDMA-E are pore-forming proteins targeting the plasma membrane to trigger a rapid cell death termed pyroptosis or bacterial membranes to promote antibacterial immune defenses.
Emilie, Bourdonnay, Thomas, Henry
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Gasdermins: making pores for pyroptosis

Nature Reviews Immunology, 2021
Feng Shao highlights the studies that led to the discovery and definition of pyroptosis as gasdermin-mediated programmed necrotic cell death.
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Inflammasome and gasdermin signaling in neutrophils

Molecular Microbiology, 2022
AbstractInflammasomes and gasdermins mount potent host defense pathways against invading microbial pathogens, however, dysregulation in these pathways can drive a variety of inflammatory disorders. Neutrophils, historically regarded as effector phagocytes that drive host defense via microbial killing, are now emerging as critical drivers of immunity in
See Jie Yow, Hui Wen Yeap, Kaiwen W. Chen   +2 more
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