Results 151 to 160 of about 9,492 (194)

Selection of DNA Aptamers Against Parathyroid Hormone for Electrochemical Impedimetric Biosensor System Development

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT This work presents the pioneering development of an aptamer‐based electrochemical biosensor for real‐time monitoring of parathyroid hormone (PTH) levels, with a focus on intraoperative assessment during parathyroid surgery. It introduces, for the first time, the selection and characterization of aptamers targeting distinct segments of the PTH ...
Reza Didarian, Saharnaz Bargh, Almina Gülerman, Veli Cengiz Özalp, Özcan Erel, Nimet Yildirim‐Tirgil   +5 more
wiley   +1 more source

Assessment of ethnic differences in pharmacokinetics and clinical responses of acalabrutinib between Chinese and White patients with B‐cell malignancies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to assess differences between Chinese and White patients in pharmacokinetics (PK) of, and clinical response to, acalabrutinib and its pharmacologically active major metabolite, ACP‐5862, to support recommended dosing in Chinese patients with B‐cell malignancies.
Tingting Yao, Junjie Ding, Shringi Sharma, Yunfei Li, Qianwei Xu, Peiming Ma   +5 more
wiley   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Small Intestine on a Chip Demonstrates Physiologic Mucus Secretion in the Presence of Lacticaseibacillus rhamnosus Biofilm

Biotechnology and Bioengineering, EarlyView.
Dash and coworkers have fabricated a small intestine on a chip, which encapsulates the physiology and biofilm of the small intestinal epithelium. The dynamic system showed villus differentiation within 5 days of flow, and the mucus layer and biofilm showed small intestinal characteristics.
Sanat Kumar Dash, Cláudia N. H. Marques, Gretchen J. Mahler   +2 more
wiley   +1 more source

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Epigastric electrical impedance for the quantitative determination of the gastric acidity

Physiological Measurement, 2008
Electrical impedance measurements have been used by scientists since the 1980s to investigate the gastric function. In this work, these measurements were carried out using the epigastrograph, a device generating alternating current of 32 kHz and injecting it in the gastric area of the human body with surface electrodes, located around the abdominal ...
Nicholas M. Spyrou, A C Giouvanoudi
openaire   +3 more sources

Limitations of the Use of Indicators for Determination of Acidity in the Gastric Lumina

American Journal of Physiology-Legacy Content, 1956
Hydrogen ion indicators were injected intravenously in dogs with an actively secreting exteriorized gastric flap. The flap was frozen, sectioned and observed microscopically at –18°C. Only neutral red and Prussian blue were seen microscopically in the lumina and then only when the secretory rate was depressed to essentially zero.
Thomas D. White, Warren S. Rehm, Richard H. Swigart   +2 more
openaire   +3 more sources

Determination of gastric acidity by measurement of azure a in the blood serum

The American Journal of Digestive Diseases, 1961
A tubeless gastric analysis procedure based on the azure A level in blood serum and the experimental results in three groups of individuals have been described.
Harry L. Segal, Plosscowe Rp
openaire   +3 more sources

Screening for Gastric Carcinoma by Determination of Lactic Acid Dehydrogenase Activity in the Gastric Juice

Digestion, 1972
By an indirect biochemical method, used for the first time for the purpose under study, the authors have screened a village population for cancer of the stomach. The organization, results and experiences obtained in this screening study are described. By determining the total lactic-acid dehydrogenase activity of the gastric juice, a ‘high-risk’ group ...
L. Simon, A.I. Figus
openaire   +3 more sources

A COMPACT APPARATUS FOR THE CLINICAL DETERMINATION OF GASTRIC ACIDITY

JAMA: The Journal of the American Medical Association, 1925
A rapid method for the determination of gastric acidity by means of test papers was recently described by us. 1 Since this description, we have devised a compact indicator set 2 for carrying out the method in clinical work. The apparatus consists of a small wooden case which contains ( a ) six vials of standard buffer solutions ranging in p H from 3 ...
Willey Denis, Daniel N. Silverman
openaire   +2 more sources

Further applications of blood gas analysis to gastric acidity determination

Clinica Chimica Acta, 1993
It has been shown that the transient increase in total body bicarbonate that accompanies any acceleration of gastric acid secretion (the 'alkaline tide') is derivable from the associated changes in base excess in arterial blood and is precisely equivalent to the amount of acid secreted when the latter is simultaneously recovered.
Subhi Abu-Avid, Gabriel Neumann, Yaron Niv   +2 more
openaire   +3 more sources