Results 151 to 160 of about 15,195 (301)

Prussian Blue Tablets for Cesium Decorporation: pH-Dependent Performance Under Normogastric and Hypochlorhydric Conditions in an In Vitro Gastrointestinal Model. [PDF]

Pharmaceuticals (Basel)
Martínez-Alonso B, Torrado Durán G, Pardo Laurel H, Guarnizo-Herrero V, Peña Fernández MÁ.   +4 more
europepmc   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Co-fermentation of <i>Xuxiang</i> kiwifruit juice by <i>Lacticaseibacillus paracasei</i> with other lactic acid bacteria: impacts on quality properties, nutrients, volatiles, and <i>in vitro</i> antioxidant activities. [PDF]

Food Chem X
Xie S, Wang R, Xiao X, Zhang W, Pan Z, Shu C, Chen J, Yang X, Wei Y.   +8 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Developing a Chitosan/polyvinyl alcohol hydrogel for gastro-retentive release of ranitidine and enhanced anti-ulcerative properties. [PDF]

BMC Biotechnol
Sadek SA, Fahmy SR, Ali SB, Abdelfattah MA, Fahmy AM, Mansour KR, Abdullah H, Mohamed Y, Hazem N, Fayez AE, Nasr CF, Desouky GK, Hassan AW, Gaafar KM.   +13 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

<i>Agrimonia eupatoria</i> Leaf Extract Attenuates Alcohol-Induced Oxidative Stress, Ulcer and Alleviates Stomach Damage in Rats. [PDF]

Food Sci Nutr
Shareef SH, Asaad NK, Gheni NA, Fisal DN, Shakir Agha NF, Ali RT, Abdulla MA.   +6 more
europepmc   +1 more source

A Disaggregation Strategy for Nanopesticide Fabrication: Investigating the Impact of Nanosizing on Pesticide Biointeractions

Advanced Science, EarlyView.
To explore the impact of nanosizing on pesticide biointeractions, a 7‐nm (average) emamectin benzoate nanopesticide without nanocarriers or surfactants is fabricated via HOAc‐mediated disaggregation. Nanosizing enhances bioactivity against Megalurothrips usitatus and Meloidogyne enterolobii and improves plant penetration.
Jiaqi Wei, Jianxin Feng, Huiting Zhu, Kunzhong Lin, Chenhan Liu, Lin Li, Zhuoyan Xiao, Daihao Huang, Rong Liu, Huipeng Pan, Lingda Zeng, Hanhong Xu   +11 more
wiley   +1 more source

Development of Alginate-Pullulan Capsules for Targeted Delivery of Herbal Dietary Supplements in Functional Fermented Milk Products. [PDF]

Foods
Muratbayev A, Idyryshev B, Kakimov A, Bepeyeva A, Jumazhanova M, Tashybayeva M, Zhumadilova G, Muratzhankyzy N, Imangaliyeva Z, Bazanova A.   +9 more
europepmc   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source