Results 121 to 130 of about 5,337,491 (425)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Treatment of helicobacter pylori infection in atrophic gastritis [PDF]

, 2018
Helicobacter pylori (Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection.
Annibale, B, Carabotti, M, Lahner, E
core   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Gastric inflammatory myofibroblastic tumor: a case report

Surgical Case Reports
Background Inflammatory myofibroblastic tumor (IMT) of the stomach is an uncommon mesenchymal neoplasm. We present a case of gastric submucosal tumor (SMT) where the final diagnosis was IMT.
Taku Hattori, Yutaka Tanizawa, Tadakazu Shimoda, Yusuke Koseki, Kenichiro Furukawa, Keiichi Fujiya, Daisuke Aizawa, Takashi Sugino, Masanori Terashima, Etsuro Bando   +9 more
doaj   +1 more source

Robotically assisted total gastrectomy for lymphadenopathy after long-term follow-up for multiple type 1 gastric neuroendocrine tumor (NET): a case report

Surgical Case Reports, 2023
Background Type 1 gastric neuroendrine tumor (NET) is usually associated with chronic atrophic gastritis and forms multiple lesions. While most cases of type 1 gastric NET are generally slowly growing, some develop regional lymph node metastases even ...
Nozomi Funatsu, Kentaro Hara, Maki Takagi, Atsushi Onodera, Kohdai Ueno, Kazuya Endo, Haruhiko Cho   +6 more
doaj   +1 more source

Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis. [PDF]

, 2017
Helicobacter pylori is a gram-negative, microaerophilic bacterium that infects the stomach and can lead to, among other disorders, the development of gastric cancer. The inability of the host to clear the infection results in a chronic inflammatory state
Butcher, Lindsay D, Crowe, Sheila E, den Hartog, Gerco, Ernst, Peter B   +3 more
core   +2 more sources

Japanese gastric cancer treatment guidelines 2014 (ver. 4)

Gastric Cancer, 2016
This English edition was made based on the Japanese version published as a book in 2014. Our policy in compiling this edition was to attempt not to include new evidence that emerged since the publication of the Japanese version so as to maintain ...
Japanese Gastric Cancer Association
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Stomach One-Point Cancer: One Case Report and Literature Review [PDF]

, 2009
Gastric cancer is one of the most common cancers and one of themost frequent causes of cancer deaths worldwide. Early detection andaccurate preoperative staging of gastric cancer is essential for planning optimal therapy such as endoscopic mucosal ...
B.Y. Zhao, Chengzhong Xing, G.W. Zhang, H.Y. Chen, Hao Zhang, Huimian Xu, Meixian Wang, P.F. Zhang, Q.X. Chen   +8 more
core   +2 more sources

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source