Results 41 to 50 of about 54,024 (306)

Dose-dependent effect of ghrelin on gastric emptying in rats and the related mechanism of action

open access: yesKaohsiung Journal of Medical Sciences, 2016
The aim of this study was to investigate the dose-dependent effect of ghrelin on gastric emptying in rats and the related mechanism of action. Sixty Wistar rats were randomized into control and test groups, which respectively received intraperitoneal ...
Shu-Guang Cao, Hao Wu, Zhen-Zhai Cai
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Prevalence and clinical determinants of diabetic gastroparesis in type 2 diabetes: a symptom- and scintigraphy-based cross-sectional study

open access: yesBMC Gastroenterology
Background Diabetic gastroparesis (DG) is a frequently underdiagnosed complication of type 2 diabetes mellitus (T2D), characterized by delayed gastric emptying without mechanical obstruction.
Marwa M Abokresha   +4 more
doaj   +1 more source

Gastric emptying and obesity

open access: yesGastroenterology, 1983
Abnormal gastric emptying in the obese has been previously suggested. To explore this concept, we studied a group of 77 subjects composed of 46 obese and 31 age-, sex-, and race-matched nonobese individuals. All of the subjects underwent quantitative fluid/solid gastric emptying assays utilizing a dual radionuclide technique. For the solid phase, obese
R A, Wright   +4 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Preoperative fasting for the infusion of “yerba mate”: a randomized clinical trial with ultrasound evaluation of gastric contents

open access: yesBrazilian Journal of Anesthesiology, 2022
Background: The traditional infusion of “yerba mate” is widely consumed in South America and exported to countries around the world. Although generally considered a “clear fluid”, there is no data to date on the gastric emptying time of yerba mate and ...
Paola Alcarraz   +8 more
doaj   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi   +9 more
wiley   +1 more source

To return or to discard? Randomised trial on gastric residual volume management

open access: yes, 2013
Background: The control of gastric residual volume (GRV) is a common nursing intervention in intensive care; however the literature shows a wide variation in clinical practice regarding the management of GRV, potentially affecting patients" clinical ...
Asensio Malo, Gema   +7 more
core   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Delayed gastric emptying in nondiabetic patients with end-stage kidney disease

open access: yesRenal Failure, 2022
Objective This study aimed to assess the gastric emptying capacity in nondiabetic patients with end-stage kidney disease (ESKD) by ultrasound. Methods Consecutive hemodialysis patients with ESKD (n = 37) and healthy controls (n = 37) were enrolled.
Cuiyu Wang   +6 more
doaj   +1 more source

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