Results 51 to 60 of about 875,736 (357)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Daily ingestion of alginate reduces energy intake in free-living subjects [PDF]

, 2008
Sodium alginate is a seaweed-derived fibre that has previously been shown to moderate appetite in models of acute feeding. The mechanisms underlying this effect may include slowed gastric clearance and attenuated uptake from the small intestine. In order
Anderson, Appleton, B.M. Corfe, Cani, Delargy, Draget, Haslam, Haug, He, Hill, Hill, Hoad, Howarth, J.C. Richardson, J.R. Paxman, Jimenez-Escrig, Kimura, Lavin, Lean, Marciani, Mattes, Mattes, McKeown, Oesch, Ohta, P.W. Dettmar, Pasman, Pelkman, Peters, Rigaud, Sandberg, Sigman-Grant, Smidsrod, Smith, Torsdottir, van de Ven, Vaugelade, Weststrate, Williams, Wolf   +39 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Multiple myeloma presenting in association with gastric phytobezoar

Clinical Case Reports, 2017
Key Clinical Message We present a rare case of a patient with delayed gastric emptying, gastric phytobezoar formation, and osteosclerotic bone lesions as an atypical association with multiple myeloma. Associated gastric features in myeloma, which include
Elizabeth S. Appleton, Natasha A. Lee, Alexander C. Ford   +2 more
doaj   +1 more source

Delayed gastric emptying in nondiabetic patients with end-stage kidney disease

Renal Failure, 2022
Objective This study aimed to assess the gastric emptying capacity in nondiabetic patients with end-stage kidney disease (ESKD) by ultrasound. Methods Consecutive hemodialysis patients with ESKD (n = 37) and healthy controls (n = 37) were enrolled.
Cuiyu Wang, Chao Chen, Jin Wang, Xiaohua Guo, Yuechan. C. Deng, Li Liu, Chunmei Zhao   +6 more
doaj   +1 more source

Comparison of gastric motility in patients of type 2 diabetes mellitus with various degrees of glycemic control

World Journal of Nuclear Medicine, 2021
The aim of this study was to evaluate the effect of glycemic control as estimated by glycated hemoglobin A1c (HbA1c) on gastric emptying in patients with type 2 diabetes mellitus (DM) using gastric emptying scintigraphy (GES).
Sanchay Jain, Vandana Dhingra, Ravi Kant, Ranjeeta Kumari   +3 more
doaj   +1 more source

Gastric emptying and plasma glucose response in men following ingestion of milk from different species : thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Nutritional Science at Massey University, Palmerston North, New Zealand [PDF]

, 2005
The 13 C Octanoic acid breath test (OABT) was used to measure the rate of gastric emptying of whole goat's milk (WG), whole cow's milk (WC), goat's milk infant formula (GIF) and cow's milk infant formula (CIF) in healthy, adult men.
Schnell, Nicholas John
core  

Upper gastrointestinal symptoms in autoimmune gastritis. A cross-sectional study [PDF]

, 2017
Autoimmune gastritis is often suspected for its hematologic findings, and rarely the diagnosis is made for the presence of gastrointestinal symptoms. Aims of this cross-sectional study were to assess in a large cohort of patients affected by autoimmune ...
Annibale, Bruno, Carabotti, Marilia, Esposito, Gianluca, Lahner, Edith, Sacchi, MARIA CARLOTTA, Severi, Carola   +5 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source