Results 131 to 140 of about 59,555 (264)

Effects of intraduodenally applied bile salts on pancreatic secretion [PDF]

, 1993
Lehnert, Peter, Riepl, Rudolf L.
core   +1 more source

Control of energy homeostasis by amylin [PDF]

, 2018
Amylin is an important control of nutrient fluxes because it reduces energy intake, modulates nutrient utilization by inhibiting postprandial glucagon secretion, and increases energy disposal by preventing compensatory decreases of energy expenditure in ...
Lutz, Thomas
core  

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Bidirectional Interactions Between the Gut Microbiota and Incretin-Based Therapies

Life
Obesity, insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic syndrome have been largely correlated to a reduction in bacterial load and diversity, resulting in a condition known as intestinal dysbiosis.
Vincenzo Trapanese, Annamaria Dagostino, Maria Resilde Natale, Federica Giofrè, Clara Vatalaro, Melania Melina, Francesca Cosentino, Silvia Sergi, Felice Imoletti, Rocco Spagnuolo, Franco Arturi   +10 more
doaj   +1 more source

An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang, Jianming Yan, Tongxin Yu, Zichuan An, Kaikai Lv, Chenyu Xue, Hongyang Yu, Na Dong, Anshan Shan   +8 more
wiley   +1 more source

Computational Analysis of Balanites aegyptiaca Phytochemicals as Inhibitors of Human Pancreatic α‐Amylase

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT Balanites aegyptiaca (BA) is a plant of paramount potential for the management of diabetes mellitus. The study investigates in silico studies of natural library compounds including that from BA with the assistance of network pharmacology. Balanitesin (compound 1) exhibited the highest docking score and binding free energy (∆G) values of −14 ...
Surendra Kumar Gautam, Rakesh Kumar Paul, Smita Jain, Iqrar Ahmad, Ammar A. Razzak Mahmood, Harun Patel, Penke Vijaya Babu, Muhammad Wahajuddin, Kaisar Raza   +8 more
wiley   +1 more source

Integrating the inputs that shape pancreatic islet hormone release. [PDF]

, 2019
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
core  

Severe Euglycemic Diabetic Ketoacidosis Requiring Intubation After Tirzepatide and SGLT2 Inhibitor Coadministration in a Patient With Type 1 Diabetes Mellitus From a Large Tertiary Care Centre in Karachi, Pakistan: A Case Report and Brief Review of the Literature

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Euglycemic diabetic ketoacidosis (euDKA) is an uncommon but potentially life‐threatening complication that may arise in patients treated with incretin‐based therapies or Sodium–Glucose Cotransporter‐2 (SGLT2) inhibitors. We report a 41‐year‐old female with Type 1 Diabetes Mellitus (T1DM) who developed severe euDKA after initiating tirzepatide ...
Maliha Malik, Hammad Amjad, Khadija Malik, Muddassir Syed Saleem, Shanzay Akhtar, Muslehuddin Paracha, Mobeen Abid, Nabahat Shafi, Ahmed Asad Raza, Abedin Samadi, Samar Abbas Jaffri   +10 more
wiley   +1 more source

The Mediators of Bile Action on the Exocrine Pancreas [PDF]

, 1993
Baba N, Beauchamp R D, Björnsson O G, Bondesen S, Burhol P G, Burhol P G, Burhol P G, Burhol P G, Chayvialle J A, Chey W Y, Davies H A, Domschke S, Fahrenkrug J, Feurle G E, Fiedler F, Fiedler F, Flaten O, Forell M M, Forell M M, Fölsch U R, Gomez G, Gomez G, Gomez G, Gomez G, Greeley G H, Grundy S M, Hanssen L E, Hanssen L E, Hanssen L E, Hoist J J, Hoist J J, Hoist J J, Häcki W H, Imamura M, Imamura M, Khalil T, Konturek S J, Koop I, Koop I, Koop I, Koop I, Koop I, Koop I, Koop I, Larsson L I, Layer P, Lehnert P, Londong W, Londong W, Lonovics J, Malagelada J R, Mellanby J, Miyasaka K, Nakaba H, Nakamura R, Nakamura R, Nustede R, Ohta H, Osnes M, Osnes M, Osnes M, P. Lehnert, Petersen H, R. L. Riepl, Rhodes J, Riepl R L, Riepl R L, Riepl R L, Sakamoto T, Schaffalitzky de Muckadell O B, Schwartz T W, Shiratori K, Singer M V, Singer M V, Singer M V, Solomon T E, Tsuchiya T   +76 more
core   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, Volume 4, Issue 2, February 2026.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source