Results 111 to 120 of about 19,776 (223)

Whole‐Genome Bisulfite Sequencing Identifies Blood‐Based DNA Methylation Biomarker for Hepatocellular Carcinoma

Molecular Carcinogenesis, Volume 65, Issue 5, Page 603-614, May 2026.
ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao, Sijia Shen, Junjie Zhang, Ying Xu, Jing Peng, Hainv Gao, Lanjuan Li   +6 more
wiley   +1 more source

Prevalence of Endoscopic and Histological Lesions at Upper Endoscopy: A Cross-Sectional, Multicentre Study in Clinical Practice

GE: Portuguese Journal of Gastroenterology
Background/Aim: Prevalence of gastroduodenal endoscopic and histological lesions may modify over time due to different factors. We assessed both macroscopic and histological lesions currently detected at upper endoscopy performed in routine practice ...
Vincenzo De Francesco, Angelo Zullo, Arnaldo Amato, Irene Bergna, Emanuele Bendia, Giorgia Giorgini, Elisabetta Buscarini, Guido Manfredi, Sergio Cadoni, Renato Cannizzaro, Stefano Realdon, Mario Ciuffi, Orazio Ignomirelli, Paola Da Massa Carrara, Giovanni Finucci, Antonietta Di Somma, Chiara Frandina, Mariafrancesca Loria, Francesca Galeazzi, Francesco Ferrara, Carlo Gemme, Noemi Sara Bertetti, Federica Gentili, Antonio Lotito, Bastianello Germanà, Nunzia Russo, Giuseppe Grande, Rita Conigliaro, Federico Cravero, Giovanna Venezia, Riccardo Marmo, Piera Senneca, Angelo Milano, Konstantinos Efthymakis, Fabio Monica, Paolo Montalto, Mario Lombardi, Olivia Morelli, Danilo Castellani, Daniela Nigro, Roberto Festa, Sergio Peralta, Maria Grasso, Antonino Carlo Privitera, Maria Emanuela Di Stefano, Giuseppe Scaccianoce, Mariangela Loiacono, Sergio Segato, Marco Balzarini, Paolo Usai Satta, Mariantonia Lai, Raffaele Manta   +51 more
doaj   +1 more source

The reg4gene, amplified in the early stages of pancreatic cancer development, is a promising therapeutic target [PDF]

, 2009
This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Background]: The aim of our work was to identify the genes specifically altered in pancreatic adenocarcinoma and especially those that are ...
Closa, Daniel, Ferrés-Masó, Montse, Folch-Puy, Emma, Iovanna, Juan Lucio   +3 more
core   +2 more sources

The Evolving Therapeutic Landscape of Gallic Acid: A Review of Mechanistic Insights and Clinical Potential

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
wiley   +1 more source

Helicobacter Pylori and Gastric Precancerous Lesions: An update

Gazi Medical Journal, 2015
Gastric cancer (GC) develops through a multistep process known as the gastritis-atrophy-metaplasia-dysplasia-cancer sequence associated with alterations in the expression of host oncogenes and tumor suppressor genes after several decades. Helicobacter pylori (H.
Alizadeh, Nasser, Saygili, Fatih, YILDIZ, RAMAZAN, İBİŞ, MEHMET, Onal, Ibrahim Koral, Kurt, Mevlut   +5 more
openaire   +4 more sources

Helicobacter pylori infection is associated with increased expression of macrophage migratory inhibitory factor - by epithelial cells, T cells, and macrophages - in gastric mucosa [PDF]

, 2004
The macrophage migratory inhibitory factor (MIF) plays a pivotal role in inflammatory and immune diseases; however, its role in gastrointestinal diseases has not been clarified.
Huang, XR, Lam, SK, Lan, HY, Leung, SY, Wong, BCY, Wong, WM, Xia, HHX, Yuen, ST   +7 more
core   +1 more source

Immunohistochemical expression of cell‐cycle proteins in gastric precancerous lesions

Journal of Gastroenterology and Hepatology, 2008
AbstractBackground:  The early indicator for the subject predisposed to gastric cancer is abnormal proliferation of gastric epithelial cells, such as atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia, which have been considered as precancerous lesions of gastric cancer.
Anagnostopoulos, G. K., Stefanou, D., Arkoumani, E., Karagiannis, J., Paraskeva, K., Chalkley, L., Habilomati, E., Tsianos, E., Agnantis, N. J.   +8 more
openaire   +3 more sources

Asiatic Acid Ameliorates MNNG‐Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS/PI3K/AKT/GSK3β Signaling Axis

Phytotherapy Research, Volume 40, Issue 5, Page 2210-2229, May 2026.
ABSTRACT Chronic atrophic gastritis (CAG), a widespread gastrointestinal condition, is widely acknowledged as a precursor to gastric cancer (GC). The incidence of CAG has been steadily increasing, yet effective pharmacological interventions remain unavailable.
Feifei Zhou, Cuiyu Zhu, Wanwan Yuan, Wenkun Peng, Qianqian Xu, Hongli Yang, Ruofan Cao, Ben Wang, Meiqian Wang, Hongwei Xu   +9 more
wiley   +1 more source

Whole-Exome Sequencing Identified Molecular Variants Linked to the Progression of Gastric Precancerous Lesions in Patients from Southwestern Colombia—An Exploratory Approach

Gastrointestinal Disorders
Background/Objectives: This study aimed to identify molecular variants associated with the progression of gastric precancerous lesions in a follow-up study conducted on patients from Southwestern Colombia.
Lizeth Mejia-Ortiz, Jovanny Zabaleta, Jone Garai, Luis Eduardo Bravo, Andres Castillo   +4 more
doaj   +1 more source

Src as the link between inflammation and cancer. [PDF]

, 2013
Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown.
Andrzej ePtasznik, Hung ePham, Sandy eLiu, Stephen J Pandol, Stephen J Pandol   +4 more
core   +2 more sources