Results 51 to 60 of about 501,265 (315)

Large language models: a primer and gastroenterology applications

Therapeutic Advances in Gastroenterology
Over the past year, the emergence of state-of-the-art large language models (LLMs) in tools like ChatGPT has ushered in a rapid acceleration in artificial intelligence (AI) innovation.
Omer Shahab, Bara El Kurdi, Aasma Shaukat, G. Nadkarni, A. Soroush   +4 more
semanticscholar   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Alexithymia in Gastroenterology and Hepatology: A Systematic Review

Frontiers in Psychology, 2018
Background: Alexithymia is a multifaceted personality construct that represents a deficit in the cognitive processing of emotions and is currently understood to be related to a variety of medical and psychiatric conditions.
Danilo Carrozzino, Danilo Carrozzino, Piero Porcelli   +2 more
doaj   +1 more source

Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission

The Lancet Gastroenterology and Hepatology, 2019
Summary The Asia-Pacific region is home to more than half of the global population and accounted for 62·6% of global deaths due to liver diseases in 2015.
S. Sarin, M. Kumar, M. Eslam, J. George, Mamun Al Mahtab, S. M. Akbar, J. Jia, Qiuju Tian, R. Aggarwal, D. Muljono, M. Omata, Y. Ooka, K. Han, H. Lee, W. Jafri, A. Butt, C. H. Chong, S. Lim, R. Pwu, Ding‐Shinn Chen   +19 more
semanticscholar   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission.

The Lancet Gastroenterology and Hepatology, 2019
Viral hepatitis is a major public health threat and a leading cause of death worldwide. Annual mortality from viral hepatitis is similar to that of other major infectious diseases such as HIV and tuberculosis.
Graham S. Cooke, I. Andrieux-Meyer, T. Applegate, R. Atun, Jessica Burry, H. Cheinquer, G. Dusheiko, Jordan J. Feld, C. Gore, Max G Griswold, S. Hamid, Margaret Hellard, J. Hou, J. Howell, J. Jia, N. Kravchenko, J. Lazarus, M. Lemoine, O. Lesi, Liudmyla Maistat, Brian J. McMahon, H. Razavi, T. Roberts, Bryony Simmons, M. Sonderup, C. Spearman, Bridie E Taylor, David L. Thomas, I. Waked, John W. Ward, S. Wiktor, A. Abdo, Rakesh Aggarwal, A. Aghemo, Bandar Al-Judaibi, M. Mahtab, A. Altaf, Zyaad Ameen, T. Asselah, Oidov Baatarkkhuu, Ella Barber, E. Barnes, P. Boulet, Louise Burrows, M. Butsashvili, E. Chan, C. Chow, Ben Cowie, C. Cunningham, Alexandre Araujo, G. Diap, G. Dore, J. Doyle, M. Elsayed, E. Fajardo, E. Gane, A. Getahun, D. Goldberg, T. Got, M. Hickman, A. Hill, Sharon Hutchinson, Christopher R. Jones, S. Kamili, Amreen Khan, Alice Lee, T. Lee, Jioiji Malani, T. Morris, S. Nayagam, R. Njouom, P. Ocama, A. Pedrana, R. Peeling, A. Reddy, J. Sacks, S. Sarin, Y. Shimakawa, Marcela R. Silva, Pavlo Skala, S. Taylor-Robinson, Alexander J. Thompson, M. Thursz, A. Tonganibeia, J. Wallace, James Ward, F. Wolff, P. Vickerman, J. Yau   +88 more
semanticscholar   +1 more source

British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic

Gut, 2020
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy.
N. Kennedy, Gareth-Rhys Jones, C. Lamb, R. Appleby, I. Arnott, R. M. Beattie, S. Bloom, A. Brooks, R. Cooney, R. Dart, C. Edwards, A. Fraser, D. Gaya, Subrata Ghosh, K. Greveson, R. Hansen, A. Hart, A. Hawthorne, B. Hayee, J. Limdi, C. Murray, G. Parkes, M. Parkes, K. Patel, R. Pollok, N. Powell, C. Probert, T. Raine, S. Sebastian, C. Selinger, Philip Smith, C. Stansfield, L. Younge, J. Lindsay, P. Irving, C. Lees   +35 more
semanticscholar   +1 more source

American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period

American Journal of Gastroenterology, 2022
We conducted systematic reviews of predefined clinical questions and used the Grading of Recommendations, Assessment, Development and Evaluations approach to develop recommendations for the periendoscopic management of anticoagulant and antiplatelet ...
N. Abraham, A. Barkun, B. Sauer, J. Douketis, L. Laine, Peter A. Noseworthy, J. Telford, G. Leontiadis   +7 more
semanticscholar   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source