Results 61 to 70 of about 552,178 (258)

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) [PDF]

, 2017
BACKGROUND: There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years.
Besselink, M., Löhr, J-Matthias, Ceyhan, G, Werner, J, Iglesias-Garcia, J., Lindkvist, B, Dumonceau, J.M., Markus M Lerch, Drenth, Joost, Schneider, M. Alexander, Witt, H., Kartalis, N., Enrique de Madaria, Dominguez Munoz, Enrique, Dumonceau, JM, Witt, Heiko, Akisik, F., Ewald, N., Witt, H, Bollen, Thomas, Schneider, Alexander, Hardt, P, Lerch, M.M., Ceyhan, Guerlap, Riccardo Manfredi, Bruno, Marco, Dumonceau, Jean Marc, Fockens, P, Ewald, N, de Madaria, Enrique, Lohr, J.M., Werner, J., Drenth, J.P., Jens Werner, Manfredi, R, Mayerle, J, Lerch, Markus M., Besselink, M, Gürlap Ceyhan, Hardt, Philip, Paul Fockens, Schneider, A, Rudolf, S., Dominguez-Munoz, E., Haas, S.L., Heiko Witt, Dominguez-Munoz, E, Mayerle, Julia, Drenth, JPH, Lerch, MM, Lohr, J. M., Rudolf, Sasa, Lohr, JM, Keller, J, Akisik, F, Marco Bruno, Werner, Jens, Boermeester, M., Dominguez-Munoz, Enrique, Manfredi, R., Bruno, M., Drewes, Asbjorn, Rudolf, S, Fockens, Paul, Boermeester, Marja, Brondum, F. J., Manfredi, Riccardo, Mayerle, J., Björn Lindkvist, Frøkjer J Brøndum, Fatih Akisik, Brondum, F.J., Jutta Keller, Iglesias-Garcia, Julio, Lindkvist, Björn, Boermeester, M, Lindkvist, B., Lerch, Markus M, Drewes, A., Haas, Stephan, Kartalis, Nikolaos, Drewes, Asbjorn; id_orcid, Julia Mayerle, Rosendahl, J, Brøndum, Frøkjer J., Schneider, A., Lindkvist, Björn,, Madaria, E. de, Haas, S, Hardt, P., Joost Drenth, Drenth, Joost P. H., Dumonceau, J. M., Jean‐Marc Dumonceau, Marja Boermeester, Lerch, M. M., Keller, Jutta, Kartalis, N, Akisik, Fatih, Haas, S., Marc Besselink, Asbjorn Drewes, de Madaria, E., Enrique Dominguez‐Munoz, Brondum, FJ, Dumonceau, Jean-Marc, Sasa Rudolf, Bollen, T., Stephan Haas, Nikolaos Kartalis, Madaria, Enrique de, Drenth, J., Ceyhan, Gürlap, Iglesias Garcia, Julio, Fockens, P., Drewes, A, Frøkjær, Jens Brøndum; id_orcid, J Matthias Löhr, Brøndum, Frøkjer J, Keller, J., Rosendahl, Jonas, Löhr, J. Matthias, Besselink, Marc, Ceyhan, G., Thomas Bollen, Alexander Schneider, Iglesias-Garcia, J, Rosendahl, J., Jonas Rosendahl, Philip Hardt, Nils Ewald, Julio Iglesias‐Garcia, de Madaria, E, Ewald, Nils, Bollen, T   +134 more
core   +2 more sources

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Main Characteristics of Lower Gastrointestinal Bleeding in Patients Treated at a Reference Hospital

Journal of Coloproctology
Lower gastrointestinal bleeding (LGB) originates below the angle of Treitz and can result from vascular, inflammatory, neoplastic, or traumatic causes.
Alvaro Gastaldi Nantes, Glenda Maria Abreu, Guilherme Henrique Pereira de Ávila Borges, Isabela Cruz Momm, Karina de Araujo Mazzini, Luiz Gabriel Lani, Raphael Londero de Araujo, Carlos Henrique Marques dos Santos   +7 more
doaj   +1 more source

Development and Validation of a Scoring System to Identify Individuals at High Risk for Advanced Colorectal Neoplasms Who Should Undergo Colonoscopy Screening

, 2014
[No abstract available]Cairns SR, 2010, GUT, V59, P666, DOI 10.1136-gut.2009.179804; Levin B, 2008, GASTROENTEROLOGY, V134, P1570, DOI 10.1053-j.gastro.2008.02.002; Lieberman DA, 2012, GASTROENTEROLOGY, V143, P844, DOI 10.1053-j.gastro.2012.06.001 ...
Sharara A.I., Harb A.H.
core   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Should We Measure Adenoma Detection Rate for Gastroenterology Fellows in Training?

, 2018
Background: Adenoma detection rate (ADR) is a proven quality metric for colonoscopy. The value of ADR for the evaluation of gastroenterology fellows is not well established.
Barrett, Patrick R., El-Halabi, Mustapha M., Mateo, Melissa Martinez, Fayad, Nabil F.   +3 more
core   +1 more source

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source