Results 71 to 80 of about 522,889 (310)
S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease
Advanced Science, EarlyView.S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang +12 morewiley +1 more sourceVirtual Education is the Need of the Hour for the Global Gastroenterology Community: A Survey of Leaders of Professional Gastroenterology Organizations [PDF]
Background & Aims: Since the onset of the Coronavirus disease 2019 (COVID-19) pandemic, there has been a significant opportunity to leverage virtual platforms for communication and dissemination of knowledge. An online survey was conducted to examine the Agrawal, Samagra, Kaplan, Gilaad, Moreira, Leticia, Metz, Geoffrey, Sadgehi, Anahita, Lee, Yeong Yeh, Barkun, Alan N., Makharia, Govind K., Leung, Wai K., Leddin, Desmond, Hansen-Barkun, Christopher +10 morecore +1 more sourceMain Characteristics of Lower Gastrointestinal Bleeding in Patients Treated at a Reference Hospital
Journal of ColoproctologyLower gastrointestinal bleeding (LGB) originates below the angle of Treitz and can result from vascular, inflammatory, neoplastic, or traumatic causes.Alvaro Gastaldi Nantes, Glenda Maria Abreu, Guilherme Henrique Pereira de Ávila Borges, Isabela Cruz Momm, Karina de Araujo Mazzini, Luiz Gabriel Lani, Raphael Londero de Araujo, Carlos Henrique Marques dos Santos +7 moredoaj +1 more sourceMultiscale Spatial Fusion Feature‐Driven Characterization of Gastric Cancer Invasive Margins: A Multicenter Cohort Study for Preoperative Accurate Differentiation Between T4a and T4b Subtypes
Advanced Science, EarlyView.This study develops a multi‐dimensional vision Transformer‐based model, GAVR, to accurately distinguish gastric cancer T4a/b stages preoperatively. Validated across multi‐center cohorts, it achieves excellent performance and significantly improves radiologists’ diagnostic accuracy, offering a promising tool for clinical decision‐making.Guoliang Zheng, Xiaomiao Chai, Peng Jin, Xin Xin, Yingjie Li, Chun Yang, Jia Wei, Zishuo Yan, Jingyu Zhang, Qianning Zhao, Yingchen Han, Ning Zhang, Fuze Li, Bo Qiao, Huan Wang, Huachuan Zheng, Yan Li, Xin Zhang, Yan Zhao, Wenjun Mao, Jing Zhang +20 morewiley +1 more sourceUnited European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) [PDF]
, 2017 BACKGROUND: There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years.Besselink, M., Löhr, J-Matthias, Ceyhan, G, Werner, J, Iglesias-Garcia, J., Lindkvist, B, Dumonceau, J.M., Markus M Lerch, Drenth, Joost, Schneider, M. Alexander, Witt, H., Kartalis, N., Enrique de Madaria, Dominguez Munoz, Enrique, Dumonceau, JM, Witt, Heiko, Akisik, F., Ewald, N., Witt, H, Bollen, Thomas, Schneider, Alexander, Hardt, P, Lerch, M.M., Ceyhan, Guerlap, Riccardo Manfredi, Bruno, Marco, Dumonceau, Jean Marc, Fockens, P, Ewald, N, de Madaria, Enrique, Lohr, J.M., Werner, J., Drenth, J.P., Jens Werner, Manfredi, R, Mayerle, J, Lerch, Markus M., Besselink, M, Gürlap Ceyhan, Hardt, Philip, Paul Fockens, Schneider, A, Rudolf, S., Dominguez-Munoz, E., Haas, S.L., Heiko Witt, Dominguez-Munoz, E, Mayerle, Julia, Drenth, JPH, Lerch, MM, Lohr, J. M., Rudolf, Sasa, Lohr, JM, Keller, J, Akisik, F, Marco Bruno, Werner, Jens, Boermeester, M., Dominguez-Munoz, Enrique, Manfredi, R., Bruno, M., Drewes, Asbjorn, Rudolf, S, Fockens, Paul, Boermeester, Marja, Brondum, F. J., Manfredi, Riccardo, Mayerle, J., Björn Lindkvist, Frøkjer J Brøndum, Fatih Akisik, Brondum, F.J., Jutta Keller, Iglesias-Garcia, Julio, Lindkvist, Björn, Boermeester, M, Lindkvist, B., Lerch, Markus M, Drewes, A., Haas, Stephan, Kartalis, Nikolaos, Drewes, Asbjorn; id_orcid, Julia Mayerle, Rosendahl, J, Brøndum, Frøkjer J., Schneider, A., Lindkvist, Björn,, Madaria, E. de, Haas, S, Hardt, P., Joost Drenth, Drenth, Joost P. H., Dumonceau, J. M., Jean‐Marc Dumonceau, Marja Boermeester, Lerch, M. M., Keller, Jutta, Kartalis, N, Akisik, Fatih, Haas, S., Marc Besselink, Asbjorn Drewes, de Madaria, E., Enrique Dominguez‐Munoz, Brondum, FJ, Dumonceau, Jean-Marc, Sasa Rudolf, Bollen, T., Stephan Haas, Nikolaos Kartalis, Madaria, Enrique de, Drenth, J., Ceyhan, Gürlap, Iglesias Garcia, Julio, Fockens, P., Drewes, A, Frøkjær, Jens Brøndum; id_orcid, J Matthias Löhr, Brøndum, Frøkjer J, Keller, J., Rosendahl, Jonas, Löhr, J. Matthias, Besselink, Marc, Ceyhan, G., Thomas Bollen, Alexander Schneider, Iglesias-Garcia, J, Rosendahl, J., Jonas Rosendahl, Philip Hardt, Nils Ewald, Julio Iglesias‐Garcia, de Madaria, E, Ewald, Nils, Bollen, T +134 morecore +1 more source8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy
Advanced Science, EarlyView.ABSTRACT
Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li +8 morewiley +1 more sourceRisk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model
Advanced Science, EarlyView.Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen +16 morewiley +1 more sourceEuropean Society for Paediatric Gastroenterology, Hepatology, and Nutrition/European Society for Paediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe. [PDF]
, 2008 The ESPGHAN-ESPID Evidence-based Guidelines
for the Management of Acute Gastroenteritis in Children
in Europe are the outcome of an important task that
the European Society for Paediatric Gastroenterology,
Hepatology, and Nutrition (ESPGHAN) has ...Gendrel D, European Society for Paediatric Infectious D.i.s.e.a.s.e.s., Ashkenazi S, Szajewska H, European Society for Paediatric Gastroenterology, Hepatology, Albano F, Nutrition, Hoekstra JH, GUARINO, ALFREDO, Shamir R +9 morecore COVID‐19 and its effects on the digestive system and endoscopy practice
JGH Open, 2020 The Coronavirus Disease 2019 (COVID‐19) is a respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has been classified as a pandemic by the World Health Organization in March 2020.Enrik John T. Aguila, Ian Homer Y. Cua, Joseph Erwin L. Dumagpi, Carlos Paolo D. Francisco, Nikko Theodore V. Raymundo, Marianne Linley L. Sy‐Janairo, Patricia Anne I. Cabral‐Prodigalidad, Marie Antoinette DC. Lontok +7 moredoaj +1 more sourceMicroprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation
Advanced Science, EarlyView.A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou +14 morewiley +1 more source
