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Diagnosing Gastroesophageal Reflux Disease
Mayo Clinic Proceedings, 2001Gastroesophageal reflux disease (GERD) is a common condition with a variety of clinical manifestations and potentially serious complications. This article reviews available methods for diagnosing GERD. A clinical history of the classic symptoms of GERD, heartburn or acid regurgitation, is sensitive enough to establish the diagnosis in patients without ...
L A, Szarka, K R, DeVault, J A, Murray
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Gastroesophageal Reflux Disease and Obesity
Gastroenterology Clinics of North America, 2010Gastroesophageal reflux disease (GERD) is a common condition, with multifactorial pathogenesis, affecting up to 40% of the population. Obesity is also common. Obesity and GERD are clearly related, both from a prevalence and causality association. GERD symptoms increase in severity when people gain weight. Obese patients tend to have more severe erosive
Girish, Anand, Philip O, Katz
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Pathophysiology of Gastroesophageal Reflux Disease
World Journal of Surgery, 2017AbstractGastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or adjacent organs and the failure of protective mechanisms associate or not to a defective valvular mechanism at the level of the esophagogastric junction incapable of dealing with a ...
Mariano A, Menezes +1 more
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Gastroesophageal Reflux and Laryngeal Disease
Archives of Surgery, 1993We wanted to determine if surgical correction of gastroesophageal reflux disease (GERD) would affect inflammatory laryngeal lesions in a select group of patients with known GERD and chronic inflammatory laryngeal lesions.Patients with persistent inflammatory lesions in the larynx were referred for workup of GERD when these lesions were not associated ...
C W, Deveney, K, Benner, J, Cohen
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GASTROESOPHAGEAL REFLUX DISEASE IN PREGNANCY
Gastroenterology Clinics of North America, 1992Heartburn during pregnancy occurs in approximately two thirds of all pregnancies. The origin is multifactorial, but the predominant factor is a decrease in LES pressure resulting from female sex hormones, especially progesterone. Mechanical factors play a small role.
T H, Baron, J E, Richter
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Pathogenesis of gastroesophageal reflux disease
Gastroenterology Clinics of North America, 2002The pathophysiology of reflux esophagitis involves contact of the esophageal epithelium with acid-pepsin in the refluxate. For this contact to occur with sufficient duration, there must either be a combination of defects in antireflux and luminal clearance mechanisms for acid-pepsin to overwhelm a previously healthy epithelium or primary defects within
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Gastroesophageal Reflux and Pulmonary Disease
Pediatrics, 1981Chronic respiratory disease is a well-established complication of gastroesophageal reflux (GER).1-3 The elucidation of the relationship between the two events is hampered by the lack of a reliable test that indicates the presence or absence of GER and the lack of a test that consistently demonstrates that the pulmonary symptoms are directly caused by ...
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