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Antiinflamatory Agents Less Dangerous for Gastrointestinal Tract
Current Pharmaceutical Design, 2001NSAIDs represent one of the most commonly used therapeutic drug groups world wide. 1.5% of the world's population is estimated as taking NSAIDs. However, their use is not risk free and gastrointestinal (GI) lesions do appear, which is indeed the main reason for their toxicity. Frequently (50%) NSAID-induced GI lesions are asymptomatic, and perforations
M, Rodríguez-Téllez +5 more
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New therapeutic agents in gastrointestinal stromal tumours
Current Opinion in Oncology, 2019Purpose of review The aim of this study was to provide an update on the most recent developments regarding systemic treatments in the various molecular subtypes of gastrointestinal stromal tumour (GIST). Recent findings Several novel direct inhibitors of KIT and PDGFRA have entered ...
Falkenhorst, Johanna +2 more
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[Antiangiogenic agents and gastrointestinal cancers].
Gastroenterologie clinique et biologique, 2008The role of angiogenesis in tumor development and the identification of VEGF as a key factor in this process have recently led to the development of anti-angiogenic agents in the treatment of cancer. Among them, the major are those targeting the VEGF pathway, including anti-VEGF antibodies (bevacizumab) and VEGF receptor tyrosine kinase inhibitors ...
A, Lièvre +3 more
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Calcium-channel blocking agents for gastrointestinal disorders
The American Journal of Cardiology, 1985Calcium-channel blocking agents have a potential role in regulation of gastrointestinal tract function by decreasing smooth muscle contraction and possibly inhibiting cellular secretion. Most studies to date have concentrated on the ability of these drugs to inhibit smooth muscle contraction. Verapamil and diltiazem have been shown in animals (opossum,
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Nitric oxide-modulating agents for gastrointestinal disorders
Expert Opinion on Investigational Drugs, 2005Almost 20 years after the identification of the biological role of nitric oxide (NO), the full therapeutic potential of novel agents that mimic the activity of NO or interfere with its synthesis has yet to be realised for utilities involving the gastrointestinal tract.
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Effects of Pharmacological Agents on Gastrointestinal Motility
Veterinary Clinics of North America: Equine Practice, 1989The control mechanisms of gastrointestinal motility are complex. Extrinsic neurohormonal effects modulate an intrinsic system, often called the "gut brain," composed of nervous and neuropeptide components. To exert pharmacologic influence on GI motility, use is made of agents that mimic the external control system.
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[Synthesis of gastrointestinal agents].
Zeitschrift fur Gastroenterologie, 1976The importance of syntheses of biologically active polypeptides especially of gastrointestinal hormones for medical research, is analyzed; six points, as the main goals of a synthetic approach, are discussed with respect to their special significance and are confirmed by six examples.
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Recent Advances in Gastrointestinal Prokinetic Agents
2006Publisher Summary This chapter discusses various gastrointestinal prokinetic agents, such as dopamine D 2 receptor antagonists, serotonin 5-hydroxytryptamine (5-HT 4 ) receptor agonists, serotonin 5-HT 3 receptor agonists, cholecystokinin CCK a receptor antagonists, motilin receptor agonists, and μ -opioid receptor antagonists.
David A. Sandham +1 more
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Recent developments in gastrointestinal prokinetic agents
Expert Opinion on Therapeutic Patents, 2008Background: Prokinetic agents are employed to reverse impaired gastrointestinal motility arising from functional disorders such as constipation-dependent irritable bowel syndrome and functional dyspepsia, as well as chronic constipation and gastro-oesophageal reflux disease.
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