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New therapeutic agents in gastrointestinal stromal tumours
Current Opinion in Oncology, 2019Purpose of review The aim of this study was to provide an update on the most recent developments regarding systemic treatments in the various molecular subtypes of gastrointestinal stromal tumour (GIST). Recent findings Several novel direct inhibitors of KIT and PDGFRA have entered ...
Falkenhorst, Johanna +2 more
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[Antiangiogenic agents and gastrointestinal cancers].
Gastroenterologie clinique et biologique, 2008The role of angiogenesis in tumor development and the identification of VEGF as a key factor in this process have recently led to the development of anti-angiogenic agents in the treatment of cancer. Among them, the major are those targeting the VEGF pathway, including anti-VEGF antibodies (bevacizumab) and VEGF receptor tyrosine kinase inhibitors ...
A, Lièvre +3 more
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[Synthesis of gastrointestinal agents].
Zeitschrift fur Gastroenterologie, 1976The importance of syntheses of biologically active polypeptides especially of gastrointestinal hormones for medical research, is analyzed; six points, as the main goals of a synthetic approach, are discussed with respect to their special significance and are confirmed by six examples.
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Calcium-channel blocking agents for gastrointestinal disorders
The American Journal of Cardiology, 1985Calcium-channel blocking agents have a potential role in regulation of gastrointestinal tract function by decreasing smooth muscle contraction and possibly inhibiting cellular secretion. Most studies to date have concentrated on the ability of these drugs to inhibit smooth muscle contraction. Verapamil and diltiazem have been shown in animals (opossum,
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ANTIBIOTIC AND CHEMOTHERAPEUTIC AGENTS IN DISEASES OF THE GASTROINTESTINAL TRACT
JAMA: The Journal of the American Medical Association, 1952The rational use of antibiotic and chemotherapeutic agents in intestinal infections, peritonitis, and preoperative preparation of the bowel has reduced morbidity and mortality in a spectacular manner. INTESTINAL INFECTIONS Typhoid. —The work of Woodward1and others has shown that chloramphenicol (chloromycetin®) is the drug of choice in the treatment
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Nitric oxide-modulating agents for gastrointestinal disorders
Expert Opinion on Investigational Drugs, 2005Almost 20 years after the identification of the biological role of nitric oxide (NO), the full therapeutic potential of novel agents that mimic the activity of NO or interfere with its synthesis has yet to be realised for utilities involving the gastrointestinal tract.
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Chemical and Environmental Agents in Gastrointestinal Carcinogenesis
Clinics in Gastroenterology, 1981E E, Deschner +2 more
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Immunity to infectious agents in the gastrointestinal tract
Journal of the American Veterinary Medical Association, 1982A D, Befus, J, Bienenstock
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