Results 221 to 230 of about 3,166,315 (255)

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Mechanistic roles and therapeutic potential of bacteriophages in inflammatory gastrointestinal diseases. [PDF]

Microbiome Res Rep
Ding B, Fan M, Shi YP, Chen X, Duan Y.
europepmc   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

The relationship between health literacy and satisfaction with medical care in parents of children with chronic gastrointestinal diseases. [PDF]

Front Public Health
Pacut A, Duplaga M, Więcek S, Murzyn I, Prusik G, Krzesiek E, Stalony N, Kowalska-Duplaga K.   +7 more
europepmc   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Impact of Gender and Race on Gastrointestinal Diseases in Patients With Parkinson's Disease: A Nationwide Analysis. [PDF]

JGH Open
Eldesouki MH, Shaban AY, Marey MM, Rabea EM, Helal A, Seisa M, Abdelhalim O, Abosheaishaa H, Khalaf M.   +8 more
europepmc   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Lessons learned: telehealth for patients with eosinophilic gastrointestinal diseases. [PDF]

Dis Esophagus
Venkatesh RD, Hiremath G, Dai X, Anderson C, Kodroff E, Strobel MJ, Zicarelli A, Gray S, Cordell A, Dellon ES, Jensen ET.   +10 more
europepmc   +1 more source

Analysis of risk factors for delayed extubation after surgical anesthesia in obese patients undergoing abdominal laparoscopic surgery for gastrointestinal diseases: a single-center retrospective study. [PDF]

Front Cardiovasc Med
Deng M, Liu D, Wei X, Yu W, Tang F, Zhu Z.   +5 more
europepmc   +1 more source

The influence of depression onset timing after gastrointestinal diseases on dementia risk. [PDF]

Alzheimers Dement
Baek SH, Hong S, Kim JP, Seo SW, Jo DG.
europepmc   +1 more source