Results 231 to 240 of about 636,707 (315)

Chronic pain and risk of gastrointestinal diseases in middle-aged and elderly Chinese adults: The roles of depression and sleep. [PDF]

Medicine (Baltimore)
Li Q, Li X, Chen W, Zhu Z, Yang Y, Xie Y, Zhu G, Zhu H.   +7 more
europepmc   +1 more source

Reviewed article: Limongi JE, Santos KAR, Perissato IL, Faria RM. Spatial analysis of granting of social security benefits to people with gastrointestinal Chagas disease in Brazil, 2004-2016: a time series study. Epidemiol Serv Saude. 2025:34;20240622.

Valeria Orsi
openalex   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Burdens and patterns of gastrointestinal diseases in Thai children: an analysis based on Thai national health coverage data. [PDF]

BMC Public Health
Getsuwan S, Sutra S, Charoenwat B, Thepsuthammarat K, Varavithya W.   +4 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Association between chronic gastrointestinal diseases and frailty: unveiling the mediating effect of loneliness. [PDF]

BMC Public Health
Gan Y, Cai S, Huang S, Xiao H, Tao P, Zhang W.   +5 more
europepmc   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Artificial intelligence in the detection and management of eosinophilic gastrointestinal diseases: Applications, challenges, and future outlook. [PDF]

J Allergy Clin Immunol
Ketchem CJ, Gabryszewski SJ, Rothenberg ME.   +2 more
europepmc   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Therapeutic effects of curcumin on upper gastrointestinal diseases: a systematic review and meta-analysis of animal studies. [PDF]

BMC Complement Med Ther
Yeerong K, Inpan R, Aisara J, Settakorn K, Takuathung MN, Thinrungroj N, Koonrungsesomboon N.   +6 more
europepmc   +1 more source