Variable selection for sparse Dirichlet-multinomial regression with an application to microbiome data analysis [PDF]
Annals of Applied Statistics 2013, Vol. 7, No. 1, 418-442, 2013 With the development of next generation sequencing technology, researchers have now been able to study the microbiome composition using direct sequencing, whose output are bacterial taxa counts for each microbiome sample. One goal of microbiome study is to associate the microbiome composition with environmental covariates.
arxiv +1 more source
The Gut Microbiome in Neuromyelitis Optica. [PDF]
, 2017 Neuromyelitis optica (NMO) is a rare, disabling, sometimes fatal central nervous system inflammatory demyelinating disease that is associated with antibodies ("NMO IgG") that target the water channel protein aquaporin-4 (AQP4) expressed on astrocytes ...
Baranzini, Sergio E +3 more
core +1 more source
The rest of the story: the microbiome and gastrointestinal infections [PDF]
Current Opinion in Microbiology, 2015 Bacterial infectious diseases are studied primarily as a host-pathogen dyad. However it is increasingly apparent that the gut microbial community is an important participant in these interactions. The gut microbiota influences bacterial infections in a number of ways, including via bacterial metabolism, stimulation of host immunity and direct bacterial
Jhansi L Leslie, Vincent B Young
openaire +3 more sources
The gut microbiome: Relationships with disease and opportunities for therapy. [PDF]
, 2019 Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age.
Durack, Juliana, Lynch, Susan V
core
Impact of amoxicillin-clavulanate followed by autologous fecal microbiota transplantation on fecal microbiome structure and metabolic potential [PDF]
, 2018 The spread of multidrug resistance among pathogenic organisms threatens the efficacy of antimicrobial treatment options. The human gut serves as a reservoir for many drug-resistant organisms and their resistance genes, and perturbation of the gut ...
Bulow, Christopher +13 more
core +2 more sources
A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness. [PDF]
, 2020 Gastrointestinal infections can be life threatening, but not much is known about the host's genetic contribution to susceptibility to gastrointestinal infections or the latter's association with psychiatric disorders.
Appadurai, Vivek +13 more
core +2 more sources
The equine gastrointestinal microbiome: Impacts of weight-loss [PDF]
BMC Veterinary Research, 2019 Abstract Background Obesity is an important equine welfare issue. Whilst dietary restriction is the most effective weight-loss tool, individual animals range in their weight-loss propensity. Gastrointestinal-derived bacteria play a fundamental role in host-health and have been associated with obesity and weight-loss in other species. This study
Philippa Morrison +8 more
openaire +5 more sources
Association of Chorioamnionitis with Aberrant Neonatal Gut Colonization and Adverse Clinical Outcomes. [PDF]
, 2016 ObjectiveChorioamnionitis (inflammation of the placenta and fetal membranes) and abnormal gastrointestinal colonization have been associated with an increased risk of sepsis and death in preterm infants, but whether chorioamnionitis causes abnormal ...
Ambalavanan, Namasivayam +5 more
core +1 more source
LinDA: linear models for differential abundance analysis of microbiome compositional data [PDF]
arXiv, 2021 Differential abundance analysis is at the core of statistical analysis of microbiome data. The compositional nature of microbiome sequencing data makes false positive control challenging. Here, we show that the compositional effects can be addressed by a simple, yet highly flexible and scalable, approach.
arxiv
Characterization of the fecal microbiome in cats with inflammatory bowel disease or alimentary small cell lymphoma. [PDF]
, 2019 Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL).
Ackermann, Mark R +9 more
core +1 more source