Results 71 to 80 of about 117,099 (295)

An iterative workflow for mining the human intestinal metaproteome [PDF]

, 2011
Background Peptide spectrum matching (PSM) is the standard method in shotgun proteomics data analysis. It relies on the availability of an accurate and complete sample proteome that is used to make interpretation of the spectra feasible.
Vos, W.M., de, Schaap, Peter, Willem M de Vos, Peter J Schaap, Boeren, S., Christian Beauvallet, Rooijers, Koos, Juste Catherine, Joël Doré, Doré Joël, Beauvallet, Christian, Been, M., de, Rooijers, K., de Been Mark, Schaap, P.J., Dore, Joel, Pilar Galan, Boeren Sjef, Beauvallet, C., Koos Rooijers, de Vos, W.M., Kolmeder, C., Schaap Peter J, Kolmeder, Carolin, Boeren, Sjef, de Vos, Willem M., de Been, Mark, Catherine Juste, Kolmeder Carolin, Galan, P., Doré, J., Rooijers Koos, Juste, C., Galan, Pilar, Mark de Been, Galan Pilar, Sjef Boeren, Beauvallet Christian, de Vos Willem M, de Vos, Willem, Juste, Catherine, Schaap, Peter J., de Been, M., Carolin Kolmeder   +43 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Baseline gut microbiome alpha diversity predicts chemotherapy-induced gastrointestinal symptoms in patients with breast cancer

npj Breast Cancer
Chemotherapy frequently causes debilitating gastrointestinal symptoms, which are inadequately managed by current treatments. Recent research indicates the gut microbiome plays a role in the pathogenesis of these symptoms.
Lauren D. Otto-Dobos, Lindsay D. Strehle, Brett R. Loman, Melina M. Seng, Sagar D. Sardesai, Nicole O. Williams, Margaret E. Gatti-Mays, Daniel G. Stover, Preeti K. Sudheendra, Robert Wesolowski, Rebecca R. Andridge, Michael T. Bailey, Leah M. Pyter   +12 more
doaj   +1 more source

An investigation of a Mollicute-like organism inhabiting the human gastrointestinal tract [PDF]

, 2009
The microflora inhabiting the human gastrointestinal tract can be considered an essential 'metabolic organ', in a symbiotic relationship with its host. Due to the low cultivability and inappropriate sampling methodology the microflora is poorly explored ...
Care, Andrew Shane
core  

Diet and Gut Microbiome in Gastrointestinal Disease [PDF]

, 2022
This is the peer reviewed version of the following article: Trakman, G. L., Fehily, S., Basnayake, C., Hamilton, A. L., Russell, E., Wilson-O'Brien, A., and Kamm, M. A. (2022) Diet and gut microbiome in gastrointestinal disease.
Sasha Fehily (11637979), Gina Trakman (9474770), Amy L Hamilton (11637985), Erin Russell (11637988), Michael A Kamm (11637994), Amy Wilson – O’Brien (11637991), Chamara Basnayake (11637982)   +6 more
core   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the CARRA, SPARTAN, and PRCSG Advisory Council   +9 more
wiley   +1 more source

Advances in microbiome in gastrointestinal cancer

Holistic Integrative Oncology
Gastrointestinal cancers are among the top cancers worldwide. The interaction between gut microbiome and tumorigenesis of gastrointestinal tract has received much attention over the past decade.
Chi Chun Wong, Jun Yu
doaj   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

The gut microbiome: an orchestrator of xenobiotic metabolism

Acta Pharmaceutica Sinica B, 2020
Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism. The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter the metabolic outcome of pharmaceuticals, environmental toxicants,
Stephanie L. Collins, Andrew D. Patterson   +1 more
doaj   +1 more source