Heterogeneity of the gut microbiome in mice : guidelines for optimizing experimental design [PDF]
, 2015 Targeted manipulation of the gut flora is increasingly being recognized as a means to improve human health. Yet, the temporal dynamics and intra- and interindividual heterogeneity of the microbiome represent experimental limitations, especially in human ...
Brinkman, Brigitta +4 more
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Role of the microbiome in non-gastrointestinal cancers
World Journal of Clinical Oncology, 2016 "The forgotten organ", the human microbiome, comprises a community of microorganisms that colonizes various sites of the human body. Through coevolution of bacteria, archaea and fungi with the human host over thousands of years, a complex host-microbiome relationship emerged in which many functions, including metabolism and immune responses, became ...
Shenghong Zhang +6 more
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A Bayesian Zero-Inflated Negative Binomial Regression Model for the Integrative Analysis of Microbiome Data [PDF]
arXiv, 2018 Microbiome `omics approaches can reveal intriguing relationships between the human microbiome and certain disease states. Along with the identification of specific bacteria taxa associated with diseases, recent scientific advancements provide mounting evidence that metabolism, genetics and environmental factors can all modulate these microbial effects.
arxiv
Micromanagement in the gut : microenvironmental factors govern colon mucosal biofilm structure and functionality [PDF]
, 2015 The human gut microbiome provides us with functional features that we did not have to evolve ourselves and can be viewed as a structured microbial community that operates like a microbial organ within the human host.
De Weirdt, Rosemarie, Van de Wiele, Tom
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In silico identification of bacteriocin gene clusters in the gastrointestinal tract, based on the Human Microbiome Project’s reference genome database [PDF]
, 2015 peer-reviewedBackground The human gut microbiota comprises approximately 100 trillion microbial cells which significantly impact many aspects of human physiology - including metabolism, nutrient absorption and immune function ...
Cotter, Paul D. +5 more
core +1 more source
Sparse tree-based clustering of microbiome data to characterize microbiome heterogeneity in pancreatic cancer [PDF]
arXiv, 2020 There is a keen interest in characterizing variation in the microbiome across cancer patients, given increasing evidence of its important role in determining treatment outcomes. Here our goal is to discover subgroups of patients with similar microbiome profiles.
arxiv
Impact of ocean acidification on the intestinal microbiota of the marine sea bream (Sparus aurata L.) [PDF]
, 2019 Within a scenario of increasing atmospheric CO2 and ocean acidification (OA), it is highly relevant to investigate its impacts not only on fish performance but also on fish intestinal microbiome and how that reflects on host performance and health.
Banerjee +67 more
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Gut Microbiome and Disorders of the Gastrointestinal Tract
MicroorganismsThe protective intestinal epithelial barrier is constantly exposed to more than 100 trillion commensal microorganisms (bacteria, archaea, viruses, and fungi), i [...]
Alexander Hammerhøj +2 more
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A healthy gastrointestinal microbiome is dependent on dietary diversity
Molecular Metabolism, 2016 Like all healthy ecosystems, richness of microbiota species characterizes the GI microbiome in healthy individuals. Conversely, a loss in species diversity is a common finding in several disease states. This biome is flooded with energy in the form of undigested and partially digested foods, and in some cases drugs and dietary supplements.
Heiman, Mark L., Greenway, Frank L.
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The gastrointestinal microbiome: a malleable, third genome of mammals [PDF]
, 2009 Ian M. Carroll +2 more
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