Results 71 to 80 of about 915,734 (298)

Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility

Scientific Reports, 2017
The gut microbiota is involved in various physiological functions, and disturbances in the host-microbiome have been proven to contribute to the dysfunction of gut; however, whether microbiota participates in the pathogenesis of constipation remains ...
X. Ge, Wei Zhao, Chao Ding, H. Tian, Lizhi Xu, Hongkan Wang, Ling Ni, Jun Jiang, J. Gong, Weiming Zhu, Min-Sheng Zhu, Ning Li   +11 more
semanticscholar   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?

Frontiers in Pharmacology
Impaired gut barrier function plays a pivotal role in the pathophysiology of irritable bowel syndrome (IBS), particularly in IBS with diarrhea. Mucoprotectants, such as xyloglucan, gelatin tannate and pea protein tannins, offer a novel therapeutic ...
Francesco Rettura, Francesco Rettura, Francesco Rettura, Christian Lambiase, Christian Lambiase, Riccardo Tedeschi, Riccardo Tedeschi, Antonio Grosso, Antonio Grosso, Lorenzo Cancelli, Lorenzo Cancelli, Angelo Ricchiuti, Angelo Ricchiuti, Andrea Bottari, Andrea Bottari, Luca Giacomelli, Nicola de Bortoli, Nicola de Bortoli, Massimo Bellini, Massimo Bellini   +19 more
doaj   +1 more source

Age-dependent changes in gastrointestinal motility

Біологічні студії, 2013
The mechanisms of the motor function are studied for more than 100 years, howe­ver, they have not been established completely. Understanding those mechanisms is of great importance since the disturbances of gastrointestinal motility underlay in ...
O. Iefimenko, I. Savchenko, T. Beregova
doaj   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Does Hypothyroidism Affect Gastrointestinal Motility?

Gastroenterology Research and Practice, 2009
Background. Gastrointestinal motility and serum thyroid hormone levels are closely related. Our aim was to analyze whether there is a disorder in esophagogastric motor functions as a result of hypothyroidism. Materials and Methods.
Olga Yaylali, Suna Kirac, Mustafa Yilmaz, Fulya Akin, Dogangun Yuksel, Nese Demirkan, Beyza Akdag   +6 more
doaj   +1 more source

Cannabinoids and Gastrointestinal Motility: Pharmacology, Clinical Effects and Potential Therapeutics in Humans

Neurogastroenterology and Motility, 2018
Cannabinoid agents and cannabis are frequently used for relief of diverse gastrointestinal symptoms.
Michael Camilleri
semanticscholar   +1 more source

Evaluation of Albizia lebbeck and Curcuma longa Extracts on Gastrointestinal Motility, Safety, and Hematological Parameters: A Sub-Chronic Toxicity and Pharmacological Study [PDF]

Asia Pacific Journal of Medical Toxicology
Background: Gastrointestinal disorders are prevalent worldwide, necessitating effective and safe therapeutic options. The use of herbal medicine dates back thousands of years, with various cultures employing plants to treat ailments.
Bushirat Fagbohun, Hassan Adewuyi, Maryam Musa, Ojochenemi Unuata, Ochonung Ogar, Agor Achi, Usman Mohammed, Jaiyeola Olukayode   +7 more
doaj   +1 more source

Cholinergic activation of enteric glia is a physiological mechanism that contributes to the regulation of gastrointestinal motility.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2018
The reflexive activities of the gastrointestinal tract are regulated, in part, by precise interactions between neurons and glia in the enteric nervous system (ENS).
Ninotchska M Delvalle, D. Fried, Gretchen Rivera‐Lopez, Lukas Gaudette, Brian D. Gulbransen   +4 more
semanticscholar   +1 more source