Results 61 to 70 of about 970,087 (354)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A comprehensive Mendelian randomization study highlights the relationship between psychiatric disorders and non-tumor gastrointestinal diseases

Frontiers in Genetics
ObjectivePrevious observational studies revealed the potential correlation between psychiatric disorders (PDs) and non-tumor gastrointestinal diseases (NTGDs).
Xiru Liang, Xiru Liang, Xindi Huang, Xindi Huang, Yutong Cheng, Yutong Cheng, Ziwei Wang, Ziwei Wang, Yahua Song, Yahua Song, Qiuai Shu, Qiuai Shu, Ning Xie, Ning Xie, Ning Xie, Ning Xie   +15 more
doaj   +1 more source

Wireless Monitoring of Gastrointestinal Transit Time, Intra-Luminal Ph, Pressure and Temperature in Experimental Pigs: A Pilot Study

Acta Medica, 2023
Background: There is no single gold standard for investigation of gastrointestinal motility function. Wireless motility monitoring involves a novel concept which provides a complex information on gastrointestinal function (gastrointestinal transit time ...
Jan Bureš, Věra Radochová, Jaroslav Květina, Darina Kohoutová, Martin Vališ, Stanislav Rejchrt, Jana Žďárová Karasová, Ondřej Soukup, Štěpán Suchánek, Miroslav Zavoral   +9 more
doaj   +1 more source

The Interplay between Hormones and Irritable Bowel Disease [PDF]

, 2013
Thesis (M.A.)--Boston UniversityThis thesis examines the underlying mechanisms causing the severe and often debilitating symptoms associated with both Irritable Bowel Syndrome and Inflammatory Bowel Disease.
Linson, Elyse A.
core   +1 more source

Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome. [PDF]

, 2012
Background/aimsCampylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens that cause PI-IBS. We
Alpern, Joel, Barlow, Gillian M, Chang, Christopher, Hwang, Laura, Jee, Sam-Ryong, Khoshini, Reza, Low, Kimberly, Marsh, Zachary, Morales, Walter, Pimentel, Mark, Pokkunuri, Venkata, Wang, Hanlin, Weitsman, Stacy   +12 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The enteric nervous system : new developments and emerging concepts [PDF]

, 2011
The enteric nervous system (ENS) is an integrative neuronal network, organized in two ganglionated plexuses, myenteric and submucosal, composed of neurons and enteric glial cells, controlling the activity of the smooth muscle of the gut, mucosal ...
Garzia Zizzo, Maria, Mastropaolo, Mariangela, Serio, Rosa   +2 more
core  

Pyridostigmine in pediatric Intestinal pseudo-obstruction. case report of a 2-year old girl and literature review [PDF]

, 2019
Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes.
Caló, Girolamo, De Giorgio, Roberto, Di Nardo, Giovanni, Esposito, Francesco, Morlando, Alessia, Parisi, Pasquale, Stanghellini, Vincenzo, Villa, Maria Pia, Viscogliosi, Federica   +8 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source