Results 51 to 60 of about 915,734 (298)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Combining endoscopic variceal ligation and omeprazole sodium in treating upper gastrointestinal hemorrhage combined with liver cirrhosis

BMC Gastroenterology
Background Cirrhosis, a common chronic liver disease, leads to portal hypertension and complications like ascites and variceal bleeding. Endoscopic variceal ligation (EVL) is the preferred treatment for variceal bleeding.
Changfang Xie, Shilei Gong, Zhenfeng Zhao, Lu Liu, Lu Lu, Jin Zhou, Xiaohuan Yu, Ying Xiong   +7 more
doaj   +1 more source

An effective and efficient technique for pyloric sphincter endoscopic functional lumen imaging probe placement using an extra-large-channel therapeutic endoscope

VideoGIE
Background and Aims: Pyloric sphincter impedance planimetry (endoscopic functional lumen imaging probe [EndoFLIP]) is increasingly used to evaluate for pyloric dysfunction in patients with gastroparesis.
Jane E. Lim, MD, MS, Nicha Wongjarupong, MD, Ali Rezaie, MD, MSc   +2 more
doaj   +1 more source

Sexual Dimorphism in Upper Gastrointestinal Motility is Dependent on Duration of Fast, Time of Day, Age, and Strain of Mice

Neurogastroenterology and Motility, 2019
An important limitation of gastrointestinal motility testing is high variability. Conditions that could contribute to variability, including the duration of pretest fasting and time of day, are rarely reported and have not been examined systematically ...
Krishnakant G. Soni, Tripti Halder, M. Conner, Geoffrey A. Preidis   +3 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A comprehensive Mendelian randomization study highlights the relationship between psychiatric disorders and non-tumor gastrointestinal diseases

Frontiers in Genetics
ObjectivePrevious observational studies revealed the potential correlation between psychiatric disorders (PDs) and non-tumor gastrointestinal diseases (NTGDs).
Xiru Liang, Xiru Liang, Xindi Huang, Xindi Huang, Yutong Cheng, Yutong Cheng, Ziwei Wang, Ziwei Wang, Yahua Song, Yahua Song, Qiuai Shu, Qiuai Shu, Ning Xie, Ning Xie, Ning Xie, Ning Xie   +15 more
doaj   +1 more source

Enteric Glia Regulate Gastrointestinal Motility but are not Required for Maintenance of the Epithelium in Mice

Gastroenterology, 2017
Background & Aims When the glial fibrillary acidic protein (GFAP) promoter is used to express cellular toxins that eliminate glia in mice, intestinal epithelial permeability and proliferation increase; this led to the concept that glia are required for ...
M. Rao, Daniella Rastelli, Lauren Dong, S. Chiu, W. Setlik, M. Gershon, G. Corfas   +6 more
semanticscholar   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Wireless Monitoring of Gastrointestinal Transit Time, Intra-Luminal Ph, Pressure and Temperature in Experimental Pigs: A Pilot Study

Acta Medica, 2023
Background: There is no single gold standard for investigation of gastrointestinal motility function. Wireless motility monitoring involves a novel concept which provides a complex information on gastrointestinal function (gastrointestinal transit time ...
Jan Bureš, Věra Radochová, Jaroslav Květina, Darina Kohoutová, Martin Vališ, Stanislav Rejchrt, Jana Žďárová Karasová, Ondřej Soukup, Štěpán Suchánek, Miroslav Zavoral   +9 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source