Results 191 to 200 of about 1,018,866 (382)

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self‐Supervised Learning

Advanced Science, EarlyView.
CRCFound is a self‐supervised learning‐based CT image foundation model for colorectal cancer (CRC). Pretrained on 5137 unlabeled CRC CT images, it learns universal feature representations, enabling efficient adaptation to various clinical tasks. The model demonstrates outstanding performance and generalization across multiple diagnostic and prognosis ...
Jing Yang, Du Cai, Junwei Liu, Zhenfeng Zhuang, Yibin Zhao, Feng‐ao Wang, Chenghang Li, Chuling Hu, Baowen Gai, Yiping Chen, Yixue Li, Liansheng Wang, Feng Gao, Xiaojian Wu   +13 more
wiley   +1 more source

O6-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms

, 2020
Hirofumi Watanabe, Yuto Yamazaki, Fumiyoshi Fujishima, Izumi Komoto, Masayuki Imamura, Susumu Hijioka, Kazuhiro Toriyama, Yasushi Yatabe, Atsushi Kudo, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano   +11 more
openalex   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

The Study of Gastrointestinal Lymphoma Immunophenotypes in Admitted Patients of Hamadan Hospitals and Relationship between 2 Years Survival with Patient Age, Immunophenotype and Site of the Tumor

پزشکی بالینی ابن سینا, 2013
Introduction & Objective: 40% lymphomas are extranodal and gastrointestinal (GI) tract is the most common site. Gastrointestinal lymphomas by definition have not liver, spleen, lymph node and bone marrow involvement.
Arash Dehghan, Azadeh Ghadiri, Mohammad Ali Seifrabiee, Mohammad Jafari, Alireza Monsef   +4 more
doaj  

Síndrome de estenose pilórica por adenocarcinoma de piloro

Revista do Colégio Brasileiro de Cirurgiões
We present a case of primary malignant pylorus neoplasia, emphasizing its rarity, the difficulty of diagnosis and the importance of an adequate prepare before the endoscopic procedure. Literature shows that tumors compromising the first, third and fourth
Célia Regina de Oliveira Garritano, José Carlos Guimarães Gomes, Rafael Domingos da Silva, Rafael Thome da Silva de Sousa   +3 more
doaj   +1 more source

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Advanced Science, EarlyView.
Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao, Ruiyan Ma, Shuai Hao, Xuxin Tan, Xue Zeng, Rui Song, Bing Chen, Zhezhe Cao, Wei Shen, Zhenchun Luo, Jianfeng Huang, He Huang, Liangming Liu, Chenyang Duan   +13 more
wiley   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science, EarlyView.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
wiley   +1 more source

Solid pseudopapillary tumor of the pancreas mistaken for gastrointestinal stromal tumor: A case report

SAGE Open Medical Case Reports
Solid pseudopapillary epithelial neoplasms of the pancreas are rare entities, first described in 1959 by Frantz. These tumors represent less than 2% of pancreatic cancers and mainly affect young women.
Amine Achemlal, Mohamed Amine Essaoudi, Manal Jidal, Mamadou Foinke Bah, Mohammed Najih, Sidi Mohammed Bouchentouf, Sanaa Berrag, Fouad Nejjari, Tarik Adioui, Mouna Tamzaourte   +9 more
doaj   +1 more source

Soluble Transferrin Receptor Level in Patients With Gastrointestinal Neoplasm: Is It Useful for Improving Screening Efficacy?

, 2011
Seyed Amir Mirbagheri, Behtash Saeidi, Alireza Momeni, Behtash Ghazi Nezami, Kaveh Hajifathalian   +4 more
openalex   +1 more source

Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis

Advanced Science, EarlyView.
Piezoelectric biomaterials convert mechanical forces into electrical signals, offering novel strategies to restore and modulate bone microenvironments for tissue engineering. This review examines molecular dipole origins, spatial arrangements, and pseudo‐piezoelectric mechanisms and highlights dipole‐engineering techniques for osteogenesis regulation ...
Xiyao Ni, Yufei Cui, Mojtaba Salehi, Mui Ling Sharon Nai, Kun Zhou, Cian Vyas, Boyang Huang, Paulo Bartolo   +7 more
wiley   +1 more source