Results 81 to 90 of about 63,208 (240)

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Complete response to second-line chemotherapy with sunitinib of a gastrointestinal stromal tumor: A case report

, 2017
Tsuyoshi Shirakawa, Tomoya Hirata, Kosuke Maemura, Toshiyuki Goto, Yoshiya Shimao, Kosuke Marutsuka, Yuji Ueda, Ikuo Kikuchi   +7 more
openalex   +2 more sources

Supplemental Figure 1 from Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor

, 2023
Phillip Zook, Harsh B. Pathak, Martin G. Belinsky, Lawrence Gersz, Karthik Devarajan, Yan Zhou, Andrew K. Godwin, Margaret von Mehren, Lori Rink   +8 more
openalex   +1 more source

Rare Presentation of a Gastrointestinal Stromal Tumor Encapsulating the Spleen: A Case Report [PDF]

, 2023
Ashley C Calise, Zoe Leuthner, Zachary Griffith   +2 more
openalex   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

CD117‐Targeted Intraoperative Imaging of Gastrointestinal Stromal Tumor Using a Stem‐Cell‐Factor‐Labeled Fluorophore [PDF]

, 2023
Shinsuke Nomura, Shinya Yokomizo, Zhidong Wang, Homan Kang, Kai Bao, Chengeng Yang, Brian P. Rubin, Roderick T. Bronson, Satoshi Kashiwagi, Hak Soo Choi   +9 more
openalex   +1 more source

Gross Intrahepatic Mass Formation Predicts the Primary Site of Perihilar Cholangiocarcinoma Based on Molecular Pathologic Studies

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Intrahepatic cholangiocarcinoma (iCCA) and extrahepatic cholangiocarcinoma (eCCA) are clinically and genetically distinct. However, the classification of perihilar cholangiocarcinoma (phCCA) with an intrahepatic tumor mass remains unclear.
Yuki Masuda, Naoto Kubota, Ryo Takemura, Yasuhito Arai, Yuta Abe, Osamu Itano, Minoru Esaki, Tatsuhiro Shibata, Yuko Kitagawa, Hidenori Ojima   +9 more
wiley   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

A Self‐Healing Conductive PVP/SUM Hydrogel for Real‐Time Human Motion Detection

Nano Select, EarlyView.
The PVP/SUM hydrogel exhibits self‐healing, conductivity, and strong mechanical performance due to H‐bonds and dipole–dipole interactions. It elongates up to 330% and shows fracture strength between 0.9 and 1.5 MPa under varying strain rates. With a conductivity of 3.28 × 10−5 S/cm, it responds rapidly to human motion, enabling real‐time monitoring for
Vinnakoti Meghana, Illa Ramakanth
wiley   +1 more source

What is the appropriate duration of adjuvant imatinib mesylate treatment for primary gastrointestinal stromal tumors classified according to the strict definition of tumor rupture?

, 2019
Jun Lü, Yun Dai, Hua‐Long Zheng, Jian‐Wei Xie, Jia-Bin Wang, Jian‐Xian Lin, Qi‐Yue Chen, Long‐Long Cao, Mi Lin, Ru‐Hong Tu, Ze‐Ning Huang, Ju‐Li Lin, Ping Li, Chang‐Ming Huang, Chao‐Hui Zheng   +14 more
openalex   +1 more source