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Mechanisms of Gastroprotection
Scandinavian Journal of Gastroenterology, 1990Gastric mucosa is constantly exposed to various irritants, but it usually maintains its integrity owing to several lines of defense, including mucus-alkaline secretion, mucosal hydrophobicity, rich mucosal blood flow, stabilization of tissue lysosomes, maintenance of mucosal sulfhydryls, and rapid proliferation and renewal of mucosal cells ...
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Gastroprotection in neurosurgery: the practice in Great Britain
British Journal of Neurosurgery, 1997The indications for gastroprotection concurrent with corticosteroid use or as prophylaxis for stress ulceration in the neurosurgical intensive care unit remain unclear. The purpose of this study was to determine to what extent gastroprotection is practised in neurosurgical units in the British Isles.
T A Carroll, D Rawluk
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Gastroprotection by Nonprostaglandin Substances
, 1989 Cytoprotection is the term originally introduced into gastrointestinal (GI) pa-thophysiology by Robert to describe the unique feature of prostaglandins (PG) to prevent acute necrotic lesions of the GI mucosa at nonantisecretory doses. This phenomenon has been studied extensively, primarily in experimental animals, and two major categories of ...
Stanislaw J. Konturek, Jan W. Konturek
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Copper-Derivatives and Gastroprotection
, 1997 The regulation of mucosal microcirculation is involved in maintaining gastric integrity. Limitations to microvascular perfusion, either by direct vasoconstriction or by removal of endogenous vasodilator tone, can lead to the development of mucosal damage, erosion or ulcerations (Whittle, 1981).
G. P. Velo, L. Franco, E. Rizzarelli
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Veterinary Clinics of North America: Small Animal Practice, 2021
A range of gastroprotective drugs are available for the treatment of esophagitis and gastroduodenal mucosal injury including acid suppressants (ie, histamine-2 receptor antagonists, proton pump inhibitors), coating agents, prostaglandin analogs, and antacids. Of these, the proton pump inhibitors are the most effective drugs for the medical treatment of
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A range of gastroprotective drugs are available for the treatment of esophagitis and gastroduodenal mucosal injury including acid suppressants (ie, histamine-2 receptor antagonists, proton pump inhibitors), coating agents, prostaglandin analogs, and antacids. Of these, the proton pump inhibitors are the most effective drugs for the medical treatment of
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Effect of menthol in experimentally induced ulcers: Pathways of gastroprotection
Chemico-Biological Interactions, 2013 Based on ethnopharmacological indications that Mentha species may be used in the treatment of gastrointestinal diseases, this study aimed to characterize the gastroprotective mechanisms of menthol (ME), the major compound of the essential oil from ...
Ariane Leite Rozza +2 more
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Gastroprotective and Antisecretory Effects of Ebrotidine
Scandinavian Journal of Gastroenterology, 1992This study was designed to assess the gastroprotective and secretory effects of ebrotidine, a novel H2-receptor antagonist, in humans. Two groups (A and B) of male subjects with normal gastric mucosa were used. Group A (six subjects) was treated for 3 days with either ebrotidine or placebo in a randomized, crossover study, and on the 4th day 100 ml of ...
S J, Konturek +5 more
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