Results 171 to 180 of about 2,582 (208)

Gastroprotective Effect and Cytotoxicity of Labdenamides

Planta Medica, 2007
Some 18 aromatic amides from the labdane diterpenes 15-acetoxyimbricatolic acid and 15-acetoxylabd-8(9)-en-19-oic acid were prepared and assessed for their gastroprotective effect in the HCl/EtOH-induced gastric lesion model in mice. The analysis of the gastroprotective activity of the benzylamides belonging to the series 8(9)- and 8(17)-ene was ...
Izquierdo, R.A., Astudillo, L., Rodriguez, J., Theoduloz, C., Palenzuela, J.A., Schmeda-Hirschmann, G.   +5 more
openaire   +2 more sources

Role of endogenous gastrin in gastroprotection

European Journal of Pharmacology, 1995
Gastrin has a potent influence on gastric acid secretion and mucosal growth but its role in mucosal integrity has been little studied. This study investigated in rats whether gastrin protects the gastric mucosa against the damage by 100% ethanol and what are the possible mechanisms of this protection.
S J, Konturek, T, Brzozowski, W, Bielanski, A V, Schally   +3 more
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Gastroprotective activity of Trichosanthes cucumerina in rats

Journal of Ethnopharmacology, 2010
The aim of the present study was to scientifically investigate whether Trichosanthes cucumerina Linn (Family: Cucurbitaceae) has gastroprotective activity.All the experiments were conducted using Wistar strain rats (weight: 200-220 g). The food and water given to rats was withdrawn for 36 and 12h respectively, before the commencement of the experiment.
L D A M, Arawwawala, M I, Thabrew, L S R, Arambewela   +2 more
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Antisecretory and gastroprotective effects of aescine in rats

General Pharmacology: The Vascular System, 1994
1. This study was designed to determine the antisecretory effects of aescine in the perfused stomach of the anaesthetized rat. In addition, the effects of aescine on mucosal lesions produced by intragastric instillation of 1 ml of absolute ethanol, its action on the production of mucus and the possible role of PGs in aescine induced gastroprotection ...
E, Marhuenda, C, Alarcón de la Lastra, M J, Martín   +2 more
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Eicosanoid and gastroprotection by copper derivatives and NDGA

Inflammation Research, 1995
We investigated the effect of oral administration of graded doses of: nordihydroguaiaretic acid (NDGA), CuNSN, a bis(2-benzimidazolyl)thioether and CuCl2 on ethanol-induced gastric damage in the rat and the role of leukotrienes and prostaglandins in attenuating this damage.
L, Franco, G P, Velo
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Gastroprotective mechanism of Bauhinia thonningii Schum

Journal of Ethnopharmacology, 2013
Bauhinia thonningii Schum. (Cesalpiniaceae) is locally known as Tambarib and used to treat various diseases including gastric ulcer.The current study aims to evaluate the gastroprotecive mechanism(s) of methanolic (MEBT) and chloroform (CEBT) extracts of Bauhinia thonningii leaves on ethanol-induced gastric ulceration.Gastric acidity, quantification ...
Abdelwahab, S.I., Taha, M.M.E., Abdulla, M.A., Nordin, N., Hadi, A.H.A., Mohan, S., Jayapalan, J.J., Hashim, Onn Haji   +7 more
openaire   +3 more sources

Physiological role of cholecystokinin in gastroprotection in humans

American Journal of Gastroenterology, 1998
Cholecystokinin (CCK) is able to protect gastric mucosa against acute injury in experimental animals but little is known about the role of this hormone in maintaining mucosal integrity in humans. This double-blind, placebo controlled study was performed in 16 healthy volunteers.
J W, Konturek, K, Hengst, S J, Konturek, E, Sito, J, Stachura, W, Domschke   +5 more
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Gastroprotective Effect of GABA in Metabolic Stress

Bulletin of Experimental Biology and Medicine
We studied the effect of enteral administration of GABA on the gastric mucosa in male Wistar rats (n=47) with modeled metabolic stress (food deprivation for 9 days with free access to water). The relative weights of the adrenal glands and thymus were determined, and histological examination of the stomach was performed.
N S, Tropskaya, Yu V, Gurman, T S, Popova, A A, Kanibolotsky   +3 more
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Gastroprotection by 4-Methylpyrazole Against Ethanol in Humans

Digestive Diseases and Sciences, 1998
4-Methylpyrazole (4-MP), a specific inhibitor of alcohol dehydrogenase, exerts gastroprotection of unusually long duration in rats. We tested the hypothesis that pretreatment with 4-MP might protect the human gastric mucosa against alcohol-induced acute injury.
IAQUINTO G, DEL TACCA M, CUCCURULLO L, PARODI MC, GIARDULLO N, D'ONOFRIO V, NATALE G, CARIGNANI D, FERRARACCIO, Franca, SZABO S.   +9 more
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Role of prostaglandins in gastroprotection.

Digestive diseases and sciences, 1998
Numerous agents increase gastric mucosal resistance against intraluminal ulcerogens. Although the precise mechanisms of gastroprotection are uncertain, various endogenous mediators involved in gastroprotective effects have been characterized. As prostaglandins exert potent protective effects and inhibition of prostaglandin formation abolishes "adaptive
B M, Peskar, N, Maricic
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