Results 41 to 50 of about 14,999 (134)
Microbial metabolites in tumor epigenetic regulation
iMeta, Volume 5, Issue 1, February 2026.The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang +31 more
wiley +1 more source
, 2022 Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets.
Tao Zhao (341704) +13 more
core +1 more source
, 2022 Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets.
Tao Zhao (341704) +13 more
core +1 more source
Generation of a conditional Gata3 knockout allele.
, 2013 (A) The conditional Gata3 knockout allele was generated by crossing Gata3ex4GFP mice with FLPe germline deleter mice. The FLPe recombinase removed the Ires-GFP-neo cassette, thereby generating a Gata3 allele with loxP sites flanking exon 4 (Gata3flox ...
Sami Kamel Boualia (375352) +7 more
core +1 more source
, 2022 Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets.
Tao Zhao (341704) +13 more
core +1 more source
Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment
Cancer Medicine, Volume 15, Issue 1, January 2026.Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang +5 more
wiley +1 more source
Gata3 is necessary for maintenance of Ret expression.
, 2013 (A–F) Gata3 maintains Ret expression in the nephric duct at E11.5. (A) Whole mount in situ hybridization of control UGS with a Ret cRNA probe shows the smooth gradient of Ret expression along the entire length of the nephric duct.
Sami Kamel Boualia (375352) +7 more
core +1 more source
, 2022 Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets.
Tao Zhao (341704) +13 more
core +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.This study reports a rare case of bone marrow failure syndrome type 1 (BMFS1) caused by a novel de novo splicing mutation (c.1502+1G>A) in the SRP72 gene. The 6‐year‐old patient presented with aplastic anemia and pancytopenia. Genetic analysis identified the mutation, which was absent in both parents, confirming its de novo origin.
Wang Xiangwen +3 more
wiley +1 more source
, 2023 Yuting Zhao,1 Xiangzhou Zhang,1 Jie Wang,2 Yong Li,1 Yitong Wu,1 Jisong Liu1 1Department of Plastic Surgery, the Third the People’s Hospital of Bengbu, Bengbu, Anhui, People’s Republic of China; 2Department of Plastic Surgery, Affiliated People’s ...
Li Y +5 more
core