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The Role of GATA3 in Breast Carcinomas: A Review
Human Pathology, 2016GATA3 is a zinc-binding transcription factor that regulates the differentiation of many human tissue types, including the mammary gland. In surgical pathology, immunohistochemistry for GATA3 is largely used to support urothelial or breast origin in a carcinoma of unknown origin. GATA3 is sensitive but not entirely specific in this setting.
Ashley Cimino-Mathews
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Molecular Immunology, 2009 The zinc-finger transcription factors Gata3 and ThPOK have both been implicated in positive selection of double positive (DP) thymocytes towards the CD4 lineage. As in the absence of Gata3, expression of ThPOK is lacking, Gata3 may directly regulate ThPOK expression.
van Hamburg, Jan Piet +4 more
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The role of Gata3 in renin cell identity
American Journal of Physiology-Renal Physiology, 2023Gata3, a dual zinc-finger transcription factor, is responsible for the identity and localization of renin cells in the kidney. Mice with a conditional deletion of Gata3 in renin lineage cells have abnormal kidneys with juxtaglomerular cells that lose their characteristic location and are misplaced outside and around arterioles and glomeruli.
Jesus S. Neyra +4 more
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Role of GATA3 in tumor diagnosis: A review
Pathology - Research and Practice, 2021GATA binding protein 3 (GATA3) belongs to a family of transcription factors comprising six members. These proteins identify G-A-T-A containing sequences in the target gene and bind to DNA target via two zinc-finger domains. The aim of this study was to evaluate the role of GATA3 in the diagnosis of tumors and its value as a prognostic marker.
Mahdis, Khazaeli Najafabadi +5 more
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Allergen Responses Modified by a GATA3 DNAzyme
New England Journal of Medicine, 2015----
CARAMORI, Gaetano +2 more
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Combined use of SOX10 and GATA3 in mammary carcinoma
Pathology - Research and Practice, 2020The complementary coverage of different subsets of breast cancer by GATA3 and SOX10 makes their use in combination appealing for routine clinical use, but study of these markers has been largely limited to cases with high or absent ER expression. Here we report SOX10 and GATA3 immunostaining in parallel using a tissue microarray containing 246 invasive
Muhammad S, Qazi, Stephanie M, McGregor
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Incidence and significance of GATA3 positivity in gallbladder adenocarcinoma
Human Pathology, 2020GATA3 immunostaining is a sensitive marker for mammary and urothelial carcinomas. It is routinely used in surgical pathology during workup of carcinomas of unknown origin. To the best of our knowledge, this is the first focused study of GATA3 expression in gallbladder adenocarcinomas.
Wenchang Guo +4 more
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Notch Signaling Is Necessary for GATA3 Function in the Initiation of T Cell Development [PDF]
European Journal of Immunology, 2008 GATA3 and Notch1 are essential for T cell development at the earliest stage, but their mutual roles in this process remain to be clarified. In this study, we demonstrated that impairment of T lymphopoiesis in hematopoietic progenitor cells (HPC) of GATA3-
Katsuto Hozumi +2 more
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