Results 171 to 180 of about 6,168 (196)

Identification of GATA3 binding sites in Jurkat cells

Gene, 2009
Determining binding sites of transcription factors is important for understanding the transcriptional control of target genes. Although a transcription factor GATA3 plays a pivotal role in Th2 lymphocyte development, its physiological role is not clearly defined because the target genes remain largely unknown.
Masahiro, Okazaki, Genta, Maeda, Tadashige, Chiba, Takeshi, Doi, Kazushi, Imai   +4 more
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GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms

The American Journal of Dermatopathology, 2017
Abstract: Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly ...
Joana, Pardal, Uma, Sundram, M Angelica, Selim, Mai P, Hoang   +3 more
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GATA3 immunohistochemical expression in invasive urothelial carcinoma

Urologic Oncology: Seminars and Original Investigations, 2016
GATA binding protein 3 (GATA3) is a transcription factor, which belongs to a distinct family of tumor suppressor genes. It is involved in human cancer cell growth and differentiation, and plays an important role in cell proliferation and apoptosis. Although, its expression has been reported in various cancers, there are limited data in genitourinary ...
Kareem Hosny, Mohammed, Momin T, Siddiqui, Cynthia, Cohen   +2 more
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The Diagnostic Dilemma of GATA3 Immunohistochemistry in Pheochromocytoma and Paraganglioma

Endocrine Pathology, 2020
Although GATA3 has been recognized as a useful marker for mammary and urothelial carcinomas, there is large variation in GATA3 expression detected in pheochromocytoma (PC) and paraganglioma (PGL), from 90% to less than 5%. For GATA3 to be a useful diagnostic marker for PCCs/PGLs, the reasons for such discrepancy must be elucidated.
Noriko Kimura, Kiyoto Shiga, Kenichi Kaneko, Chiho Sugisawa, Takayuki Katabami, Mitsuhide Naruse   +5 more
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Value of GATA3 Immunostaining in Tumor Diagnosis

Advances in Anatomic Pathology, 2013
GATA3 is a member of a group of zinc-finger transcription factors that is involved in cell development and differentiation. Recent studies have shown that, among tumors, GATA3 is commonly expressed in both urothelial tumors and breast epithelial neoplasms. With the exception of salivary gland and parathyroid tumors, GATA3 has been reported to be either
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GATA3 expression in sarcomatoid urothelial carcinoma of the bladder

Human Pathology, 2014
The current available data on GATA-binding protein 3 (GATA3) expression in sarcomatoid urothelial carcinoma are limited, especially in the non-tissue microarray-based setting. In this study, we analyzed the expression of GATA3 in sarcomatoid urothelial carcinoma of the bladder in cystectomy/cystoprostatectomy specimens.
Nazneen, Fatima, Adeboye O, Osunkoya
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GATA3 Is Underexpressed in Penile Neoplasia

American Journal of Surgical Pathology
Penile squamous cell carcinoma (PSCC) and its established precursor, penile intraepithelial neoplasia (PeIN), are classified as HPV-associated and HPV-independent. However, there is a spectrum of precursor lesions, which presents diagnostic challenges due to morphologic overlap. Immunohistochemical loss of GATA3, a tumor suppressor
Namratha Adiyeri Kandiyil, Antonio L. Cubilla, Delia F. Tifrea, Jeffrey Kim, Christopher Rodriguez, Katharine A. Kirby, Ankur R. Sangoi, Nicholas Korvink, Farah Rahmatpanah, Sara M. Falzarano, Carlos Prieto-Granada, Giovanna A. Giannico   +11 more
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Value of GATA3 Immunostaining in the Diagnosis of Parathyroid Tumors

Applied Immunohistochemistry & Molecular Morphology, 2014
GATA3 is a transcription factor that is involved in the embryonic development of the parathyroid glands and in adult parathyroid cell proliferation. The aim of this study is to investigate the expression of GATA3 in parathyroid tumors and to determine whether it could be used as an immunohistochemical marker for parathyroid differentiation in tumors ...
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Immunohistochemical GATA3 expression in prostate adenocarcinoma: pitfalls

Journal of Immunoassay and Immunochemistry
Recent studies have reported aberrant GATA3 immunohistochemical expression in high-grade prostate carcinoma, raising concerns about its specificity. This study aimed to evaluate GATA3 immunohistochemical expression in prostate adenocarcinoma.We retrospectively collected cases of primary prostate adenocarcinoma diagnosed in our pathology department(2019-
Sarra, Ben Rejeb, Yasmine, Chaabane, Kalthoum, Dridi, Rym, Bahloul, Hassen, Khouni   +4 more
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GATA3 functions through Sox13.

We found using cells engineered to over-express Sox13 a developmental function for Sox13 proceeding through GATA3.   
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