Cell ReportsSummary: The TAL1 oncogene driving T cell lymphoblastic leukemia is frequently activated through mutated cis-regulatory elements, whereby small insertions or deletions (indels) create a binding site for the transcription factor MYB.
Joana R. Costa +21 more
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Interaction of the pioneer transcription factor GATA3 with nucleosomes [PDF]
Nature Communications, 2020 GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor ...
Hiroki Tanaka +7 more
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Mutational signatures in GATA3 transcription factor and its DNA binding domain that stimulate breast cancer and HDR syndrome [PDF]
Scientific Reports, 2021 Transcription factors (TFs) play important roles in many biochemical processes. Many human genetic disorders have been associated with mutations in the genes encoding these transcription factors, and so those mutations became targets for medications and ...
Atlal El-Assaad +3 more
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Continued expression of GATA3 is necessary for cochlear neurosensory development. [PDF]
PLoS ONE, 2013 Hair cells of the developing mammalian inner ear are progressively defined through cell fate restriction. This process culminates in the expression of the bHLH transcription factor Atoh1, which is necessary for differentiation of hair cells, but not for ...
Jeremy S Duncan, Bernd Fritzsch
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Gata3 dosage governs primitive endoderm versus trophectoderm specification in embryonic stem cells [PDF]
EMBO ReportsTranscription factor (TF) dosage represents an overlooked aspect of developmental regulation. While Gata3 has traditionally been viewed as a determinant of trophectoderm (TE), its potential role in primitive endoderm (PE) has remained unclear.
Yeejin Jang +3 more
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Plasmid-DNA Encoded gata3 and eomes Increase Antibody Response and Performance of an Inactivated Salmonid Alphavirus Subtype 3 Vaccine [PDF]
PharmaceuticsBackground: Pancreas disease, caused by salmonid alphavirus subtype 3 (SAV3), remains a significant threat to Atlantic salmon (Salmo salar L.) aquaculture in Norway despite the widespread use of inactivated vaccines.
Filipe Figueiredo +13 more
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The multi-faceted role of Gata3 in developmental haematopoiesis [PDF]
Open Biology, 2018 The transcription factor Gata3 is crucial for the development of several tissues and cell lineages both during development as well as postnatally. This importance is apparent from the early embryonic lethality following germline Gata3 deletion, with ...
Nada Zaidan, Katrin Ottersbach
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Diagnostic Utility of Trichorhinophalangeal Syndrome Type 1 (TRPS1) immunostain in breast carcinoma compared to GATA3 [PDF]
Egyptian Journal of Cancer and Biomedical Research, 2023 Background: Female breast cancer (BC) has become the most diagnosed cancer and the fifth leading cause of cancer mortality worldwide. Metastatic breast cancer is a main differential diagnosis for any suspected metastatic carcinoma in women due to its ...
Nadia Elafify +3 more
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Pan-cancer predictions of transcription factors mediating aberrant DNA methylation
Epigenetics & Chromatin, 2022 Background Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcription factors initially thought to be repressed from binding by DNA methylation, have recently ...
Dylane Detilleux +4 more
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Frontiers in Cell and Developmental Biology, 2021 USP21 is a kind of deubiquitinating enzymes involved in the malignant progression of various cancers, while its role in gastric cancer (GC) and the specific molecular mechanism are still unclear.
Qingqu Guo +6 more
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