Results 11 to 20 of about 4,830,735 (205)

Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear. [PDF]

PLoS ONE, 2009
We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model specific auditory ...
Marta Milo, Daniela Cacciabue-Rivolta, Adam Kneebone, Hikke Van Doorninck, Claire Johnson, Grace Lawoko-Kerali, Mahesan Niranjan, Marcelo Rivolta, Matthew Holley   +8 more
doaj   +10 more sources

Genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population. [PDF]

PLoS ONE, 2018
Type 2 diabetes mellitus is a multifactorial metabolic disorder caused by environmental factors and has a strong association with hereditary issues. These hereditary issues result in an imbalance in CD4+T cells and a decreased level of naïve CD4+T cells,
Nafiul Huda, Md Ismail Hosen, Tahirah Yasmin, Pankaj Kumar Sarkar, A K M Mahbub Hasan, A H M Nurun Nabi   +5 more
doaj   +5 more sources

The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons [PDF]

The Journal of Neuroscience, 2010
The transcription factor Gata3 is essential for the development of sympathetic neurons and adrenal chromaffin cells. As Gata3 expression is maintained up to the adult stage, we addressed its function in differentiated sympathoadrenal cells at embryonic ...
Grosveld, F., Kurek, Dorota, Reiff, T, Tobias Reiff, Schütz, G. (Günther), Hermann Rohrer, Jutta Stubbusch, Rohrer, H., Frank G. Grosveld, Stubbusch, J., Kurek, D. (Dorota), Günther Schütz, Tsarovina, K, Rosanna Parlato, Tsarovina, K., Reiff, T. (Tobias), Stubbusch, J, Grosveld, Frank, Rohrer, H. (Hermann), Stubbusch, J. (Jutta), Konstantina Tsarovina, Tsarovina, K. (Konstantina), Parlato, R. (Rosanna), Schutz, N., Kurek, D., Parlato, R., Rohrer, H, Parlato, R, Dorota Kurek, Reiff, T., Schutz, N, Grosveld, F.G. (Frank)   +31 more
core   +5 more sources

Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs [PDF]

Journal of Clinical Investigation, 2016
The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has pathological consequences.
Ku, Chia-Jui, タカハシ, サトル, オオイシ, ヒサシ, Engel, James Douglas, 大石, 久史, 高橋, 智, 水野, 聖哉, MIZUNO, Seiya, OISHI, Hisashi, Ohmura, Sakie, TAKAHASHI, Satoru, Hosoya, Tomonori, ミズノ, セイヤ, Hermann, Mary   +13 more
core   +7 more sources

The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA3 [PDF]

The Journal of Immunology, 2009
Recently, it was reported that the expression of Runt-related transcription factor 3 (Runx3) is up-regulated in CD4+ helper T cells during Th1 cell differentiation, and that Runx3 functions in a positive feed-forward manner with the T-box family ...
Onda, D., Kubo, M., Kohu, K., Wong, W.F., Ohmori, H., Kon, S., Satake, M., Nakayama, T., Wakoh, T., Yamashita, M.   +9 more
core   +6 more sources

ASSOCIATION BETWEEN SPECIFIC FEATURES OF GATA3 TRANSCRIPTION FACTOR EXPRESSION AND LYMPH NODE METASTASIS IN LUMINAL BREAST CANCER

Сибирский онкологический журнал, 2017
Currently, the study of the markers of cell differentiation, proliferative regulators, and molecules involved in the development of drug resistance mechanisms in breast cancer is extremely important. The transcription factor GATA3 plays an essential role
S. V. Vtorushin, D. V. Vasilchenko, К. Y. Khristenko, N. V. Krakhmal, I. V. Stepanov, М. V. Zavyalova, E. M. Slonimskaya, S. V. Patalyak   +7 more
doaj   +2 more sources

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2 [PDF]

Journal of Clinical Investigation, 2010
Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/–
Stacey, Joanna M., Kurek, Dorota, Ali, A, Grigorieva, Irina V., Nancy Manley, Fairclough, R.J. (Rebecca), Hough, D.M. (David), Rebecca J. Fairclough, Grigorieva, I.V. (Irina), Fraser, WD, Kurek, D. (Dorota), Mihai, R. (Radu), Elena F. Grigorieva, Fairclough, RJ, Irina V. Grigorieva, Manley, N, Gaynor, K.U. (Katherine), Grosveld, Frank, William D. Fraser, Nesbit, M. Andrew, Mihai, Radu, Grigorieva, E.F. (Elena), Mihai, R, Tertius Hough, Rajesh V. Thakker, Ali, Asif, Katherine U. Gaynor, Joanna M. Stacey, Nesbit, M.A. (M. Andrew), Ali, A. (Asif), Wei, QZ, Brian G. Condie, Wei, Qiaozhi, Hough, Tertius, Mirczuk, S, Stechman, MJ, Stechman, Michael J., Condie, B.G. (Brian), Manley, G. (Geoffrey), Grosveld, F.G. (Frank), Asif Ali, Thakker, R.V. (Rajesh), Frank Grosveld, Condie, Brian G., Thakker, RV, Mirczuk, S. (Samantha), Stacey, JM, Gaynor, Katherine U., Wei, Q. (Qiaozhi), Grigorieva, Elena F., Nesbit, MA, M. Andrew Nesbit, Manley, Nancy, Hough, T, Stacey, J.M. (Joanna), Samantha Mirczuk, Michael J. Stechman, Thakker, Rajesh V., Qiaozhi Wei, Mirczuk, Samantha, Grigorieva, EF, Stechman, M.J. (Michael), Grigorieva, IV, Condie, BG, Dorota Kurek, Fairclough, Rebecca J., Fraser, William D., Radu Mihai, Fraser, W.D. (William), Gaynor, KU   +69 more
core   +5 more sources

GATA3 differentially regulates the transcriptome via zinc finger 2-modulated phase separation

Cell Reports
Summary: Phase separation (PS) underlies gene control by transcription factors. However, little is known about whether and how DNA-binding domains (DBDs) regulate the PS for transcription factors to differentially regulate the transcriptome.
Yatao Chen, Yajie Wan, Xiaoying Pei, Ziqi Wei, Tan Wang, Jun Zhang, Liming Chen   +6 more
doaj   +2 more sources

PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells.

PLoS ONE, 2015
The transcription factor PU.1 is predominantly expressed in dendritic cells (DCs) and is essential for DC differentiation. Although there are several reports that PU.1 positively regulates the expression of DC-specific genes, whether PU.1 also has a ...
Takuya Yashiro, Masato Kubo, Hideoki Ogawa, Ko Okumura, Chiharu Nishiyama   +4 more
doaj   +2 more sources

Low expression of GATA3 promotes cell proliferation and metastasis in gastric cancer

Cancer Management and Research, 2017
Shuangqin Wei,1 Liang Zhong,2 Xiaoping Wang,1 Wenju Zhang3 1Department of Gastroenterology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 2Department of Gastroenterology, Huashan Hospital, Fudan University, 3School of ...
Wei S, Zhong L, Wang X, Zhang W
doaj   +1 more source