Results 31 to 40 of about 4,830,735 (205)

GATA Binding Protein 3 Is a Direct Target of Kruppel-Like Transcription Factor 7 and Inhibits Chicken Adipogenesis

Frontiers in Physiology, 2020
Kruppel-like transcription factor 7 (KLF7) is a negative regulator of adipogenesis, however, its precise mechanism is poorly understood. Our previous KLF7 ChIP-seq analysis showed that one of the KLF7 binding peaks was present upstream of GATA binding ...
Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Zhao Jin, Xinyang Zhang, Xinyang Zhang, Xinyang Zhang, Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Wenjian Zhang, Wenjian Zhang, Wenjian Zhang, Shuli Shao, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +21 more
doaj   +1 more source

Gata3 is required in late proneurosensory development for proper sensory cell formation and organization

Scientific Reports, 2023
It has previously been shown that the zinc-finger transcription factor Gata3 has dynamic expression within the inner ear throughout embryonic development and is essential for cochlear neurosensory development. However, the temporal window for which Gata3
Paige V. Blinkiewicz, Makayla R. Long, Zachary A. Stoner, Elizabeth M. Ketchum, Sydney N. Sheltz-Kempf, Jeremy S. Duncan   +5 more
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GATA3 immunoreactivity expands the transcription factor profile of pituitary neuroendocrine tumors [PDF]

Modern Pathology, 2019
The modern classification of pituitary neuroendocrine tumors relies mainly on immunohistochemistry for pituitary transcription factors, hormones, and other biomarkers, including low molecular weight cytokeratins. The transcription factor GATA2 is required for development of gonadotrophs and thyrotrophs but has not been used for classification of ...
Ozgur Mete, Mehmet Kefeli, Sultan Çalışkan, Sylvia L. Asa   +3 more
openaire   +3 more sources

Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer

Genome Biology, 2021
Muscle-invasive bladder cancers are characterized by their distinct expression of luminal and basal genes, which could be used to predict key clinical features such as disease progression and overall survival.
Tejaswi Iyyanki, Baozhen Zhang, Qixuan Wang, Ye Hou, Qiushi Jin, Jie Xu, Hongbo Yang, Tingting Liu, Xiaotao Wang, Fan Song, Yu Luan, Hironobu Yamashita, Ruby Chien, Huijue Lyu, Lijun Zhang, Lu Wang, Joshua Warrick, Jay D. Raman, Joshua J. Meeks, David J. DeGraff, Feng Yue   +20 more
doaj   +1 more source

Transcriptional regulation of FOXP3 requires integrated activation of both promoter and CNS regions in tumor-induced CD8+ Treg cells

Scientific Reports, 2017
T-regulatory cells are an upsurge in the tumor microenvironment and induce immune-evasion. CD4+ Treg cells are well characterized whereas the role of CD8+ Tregs in cancer has recently started to crease attention. Here, we report an augmentation CD8+FOXP3+
Sreeparna Chakraborty, Abir K. Panda, Sayantan Bose, Dia Roy, Kirti Kajal, Deblina Guha, Gaurisankar Sa   +6 more
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Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes. [PDF]

PLoS ONE, 2013
We have recently described the presence of the erythropoietin receptor (EPO-R) on CD4(+) lymphocytes and demonstrated that its expression increases during their activation, reaching a level reported to be typical for erythroid progenitors.
Katarzyna A Lisowska, Joanna E Frackowiak, Anna Mikosik, Jacek M Witkowski   +3 more
doaj   +1 more source

Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues

Cell Reports, 2023
Summary: Lymphoid tissue inducer (LTi) cells, a subset of innate lymphoid cells (ILCs), play an essential role in the formation of secondary lymphoid tissues.
Mingzhu Zheng, Chen Yao, Gang Ren, Kairui Mao, Hyunwoo Chung, Xi Chen, Gangqing Hu, Lei Wang, Xuemei Luan, Difeng Fang, Dan Li, Chao Zhong, Xiaoxiao Lu, Nikki Cannon, Mingxu Zhang, Avinash Bhandoola, Keji Zhao, John J. O’Shea, Jinfang Zhu   +18 more
doaj   +1 more source

Expression of FOXP3 and GATA3 Transcription Factors Among Bronchial Asthmatics in Northern Population

Indian Journal of Clinical Biochemistry, 2019
Asthma is a common chronic airways inflammatory disorder in which the expression of genes for the transcription factors FoxP3 and GATA3 plays crucial roles in activation of specific T cells population and pathogenesis of asthma. Recent data have shown that Hb, Eosinophils, total leucocytes count (TLC), absolute eosinophil count (AEC), and IgE, may be ...
Rashmi, Pandey, Ved, Prakash
openaire   +3 more sources

Brca1 Is Regulated by the Transcription Factor Gata3, and Its Silencing Promotes Neural Differentiation in Retinal Neurons

International Journal of Molecular Sciences, 2022
Previous studies have indicated that Brca1 (Breast cancer suppressor gene 1) plays an important role in neural development and degenerative diseases. However, the bioactivity and regulatory mechanism of Brca1 expression in retinal neurocytes remain unclear.
Jiejie Zhuang, Pei Chen, Yihui Wu, Qian Luo, Qiyun Wang, Shuilian Chen, Xi Chen, Zihua Jiang, Jin Qiu, Yan Li, Zhaohui Yuan, Jing Zhuang   +11 more
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Gata3ZsG and Gata3ZsG-fl: Novel murine Gata3 reporter alleles for identifying and studying Th2 cells and ILC2s in vivo

Frontiers in Immunology, 2022
T helper-2 (Th2) cells and type 2 innate lymphoid cells (ILC2s) play crucial roles during type 2 immune responses; the transcription factor GATA3 is essential for the differentiation and functions of these cell types.
Rama K. Gurram, Danping Wei, Qiao Yu, Qiao Yu, Olena Kamenyeva, Hyunwoo Chung, Mingzhu Zheng, Matthew J. Butcher, Juraj Kabat, Chengyu Liu, Jaspal S. Khillan, Jinfang Zhu   +11 more
doaj   +1 more source