Results 51 to 60 of about 4,830,735 (205)

Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation

Frontiers in Immunology
BackgroundType 2 immunity is initiated through a synergistic response between innate and adaptive immune cells to facilitate host-pathogen defense and wound repair, yet aberrant responses can contribute to chronic inflammation and allergic disease.
Erik P. Hughes, Erik P. Hughes, Asit K. Manna, Asit K. Manna, Wenxiang Sun, Sandra M. Osburn-Staker, Samuel Aamodt, Kristi J. Warren, James E. Cox, Dean Tantin, Dean Tantin   +10 more
doaj   +1 more source

Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3 [PDF]

Open Biology, 2019
Gata3 is a DNA-binding transcription factor involved in cellular differentiation in a variety of tissues including inner ear, hair follicle, kidney, mammary gland and T-cells. In a previous study in 2009, Maeda et al. (Dev. Dyn.
Elena Martynova, Yilin Zhao, Qing Xie, Deyou Zheng, Ales Cvekl   +4 more
doaj   +1 more source

Regulatory T‐lymphocytes mediate amyotrophic lateral sclerosis progression and survival

EMBO Molecular Medicine, 2012
In amyotrophic lateral sclerosis (ALS) mice, regulatory T‐lymphocytes (Tregs) are neuroprotective, slowing disease progression. To address whether Tregs and FoxP3, a transcription factor required for Treg function, similarly influence progression rates ...
Jenny S. Henkel, David R. Beers, Shixiang Wen, Andreana L. Rivera, Karen M. Toennis, Joan E. Appel, Weihua Zhao, Dan H. Moore, Suzanne Z. Powell, Stanley H. Appel   +9 more
doaj   +1 more source

GATA3 Positively Correlates with BCL2 Expression in Indolent and Aggressive Histological Types of Cutaneous Basal Cell Carcinoma [PDF]

Türk Patoloji Dergisi
Objective: Some histological basal cell carcinoma (BCC) types demonstrate more aggressive behavior than others. They are known as high-risk BCC and are more challenging in therapy, contrary to indolent (low-risk) BCC types.
Fatma Alzahraa Abdelsalam ELKHAMISY, Ahmed Naeem EESA, Marwa Kamal SALLAM, Marwa Fathy HUSSEIN, Nadia Ahmed ABD EL-MOEZE   +4 more
doaj   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder

Neurobiology of Disease, 2004
Patients with HDR syndrome suffer from hypoparathyroidism, deafness, and renal dysplasia due to a heterozygous deletion of the transcription factor GATA3.
Jacqueline van der Wees, Marjolein A.J van Looij, M.Martijn de Ruiter, Helineth Elias, Hans van der Burg, Su-San Liem, Dorota Kurek, J.Doug Engel, Alar Karis, Bert G.A van Zanten, Chris I De Zeeuw, Frank G Grosveld, J.Hikke van Doorninck   +12 more
doaj   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

GATA3 regulates FLG and FLG2 expression in human primary keratinocytes

Scientific Reports, 2017
GATA3 is a transcription factor with an important role in atopic diseases because of its role in the differentiation of Th2 lymphocytes. Moreover, GATA3 is expressed in keratinocytes and has a role in keratinocyte differentiation and the establishment of
Jana Zeitvogel, Neele Jokmin, Samira Rieker, Ilona Klug, Christina Brandenberger, Thomas Werfel   +5 more
doaj   +1 more source

GATA3 induces the pathogenicity of Th17 cells via regulating GM-CSF expression

Frontiers in Immunology, 2023
T-bet-expressing Th17 (T-bet+RORγt+) cells are associated with the induction of pathology during experimental autoimmune encephalomyelitis (EAE) and the encephalitic nature of these Th17 cells can be explained by their ability to produce GM-CSF. However,
Matthew J. Butcher, Rama Krishna Gurram, Xiaoliang Zhu, Xi Chen, Gangqing Hu, Gangqing Hu, Vanja Lazarevic, Keji Zhao, Jinfang Zhu   +8 more
doaj   +1 more source

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source