Results 61 to 70 of about 4,830,735 (205)

GATA3 expression in triple-negative breast cancers [PDF]

, 2017
AIMS: GATA-binding protein 3 (GATA3) is a well-studied transcription factor found to be essential in the development of luminal breast epithelium and has been identified in a variety of tumour types, including breast and urothelial carcinomas, making it ...
Siddhartha Deb, Stephen B Fox, Takano, EA, Deb, S, David J Byrne, Elena A Takano, Byrne, DJ, Fox, SB   +7 more
core   +1 more source

CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder [version 2; peer review: 2 approved]

F1000Research
In this datanote we present data from 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients followed throughout three years to assess their eventual phenoconversion to Parkinson’s disease and other established neurodegenerative ...
Maurizio Versino, Cristoforo Comi, Franca Marino, Michele Terzaghi, Monica Pinoli, Marco Cosentino   +5 more
doaj   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation [PDF]

, 2018
GATA-binding protein 3 (GATA3) acts as the master transcription factor for type 2 T helper (Th2) cell differentiation and function. However, it is still elusive how GATA3 function is precisely regulated in Th2 cells.
Bing Sun, Gangqing Hu, Chao Zhong, Ming Zhao, Liu, P, Fang, D, Ryoji Yagi, Zhu, J, Kairong Cui, Keji Zhao, Cui, K, Oler, AJ, Suveena Sharma, Pentao Liu, Rama Krishna Gurram, Sun, B, Zhao, K, Hu, G, Gurram, RK, Zhong, C, Jinfang Zhu, Andrew J. Oler, Zhao, M, Yagi, R, Difeng Fang, Sharma, S   +25 more
core   +1 more source

CARMA1 Controls Th2 Cell-Specific Cytokine Expression through Regulating JunB and GATA3 Transcription Factors [PDF]

The Journal of Immunology, 2012
Abstract The scaffold protein CARMA1 is required for the TCR-induced lymphocyte activation. In this study, we show that CARMA1 also plays an essential role in T cell differentiation. We have found that the adoptive transfer of bone marrow cells expressing constitutively active CARMA1 results in lung inflammation, eosinophilia, and ...
Marzenna, Blonska, Donghyun, Joo, Patrick A, Zweidler-McKay, Qingyu, Zhao, Xin, Lin   +4 more
openaire   +2 more sources

Studying GATA3, FOXA1, and ELF5 transcription factors in the evaluation of prognosis in luminal breast cancer patients

Bulletin of Siberian Medicine, 2021
Background. The identification of predictive molecular markers of luminal breast cancer will help to assess the risk of developing distant metastases and determine a personalized approach to predicting the outcome of the disease during hormone therapy.The aim of the study was to investigate the relationship between the transcription factors GATA3 ...
S. V. Vtorushin, D. V. Vasilchenko, M. V. Zavyalova, N. V. Krakhmal’, S. V. Patalyak   +4 more
openaire   +3 more sources

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber, Mario R. Angeli, Hashem Mohammadian, Hannah Labinsky, Maria Gabriella Raimondo, Richard Demmler, Yuko Ariza, Thomas Wohlfahrt, Markus Luber, Yi‐Nan Li, Jörg H.W. Distler, Tobias Bäuerle, Georg Schett, Simon Rauber, Andreas Ramming, Alina M. Ramming   +15 more
wiley   +1 more source

transcription-factor-analysis-profacgen.jpg

, 2019
Transcription factors are proteins that bind to specific DNA sequences and regulate the transcription of genetic information from DNA to messenger RNA (mRNA). They are found in all living organisms. https://www.profacgen.com/transcription-factor-analysis.
Jerry Carter (6727871)
core   +1 more source

FOXP3 and GATA3 Polymorphisms, Vitamin D3 and Multiple Sclerosis

Brain Sciences, 2021
Background: Regulatory T cells (Tregs) alterations have been implicated in the pathogenesis of Multiple Sclerosis (MS). Recently, a crucial role of the X-Linked Forkhead Box P3 (FoxP3) for the development and the stability of Tregs has emerged, and FOXP3
Concetta Scazzone, Luisa Agnello, Bruna Lo Sasso, Giuseppe Salemi, Caterina Maria Gambino, Paolo Ragonese, Giuseppina Candore, Anna Maria Ciaccio, Rosaria Vincenza Giglio, Giulia Bivona, Matteo Vidali, Marcello Ciaccio   +11 more
doaj   +1 more source

Mechanism of RNA‐Binding Protein ELAVL1 in Promoting Th2 Cell Differentiation Through Stabilizing CPA3 mRNA in Allergic Rhinitis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to elucidate the role of the RNA‐binding protein embryonic lethality abnormal vision‐like protein 1 (ELAVL1) in the pathogenesis of allergic rhinitis (AR), specifically by investigating its potential to promote T helper 2 (Th2) cell differentiation by regulating the stability of carboxypeptidase A3 (CPA3) mRNA.
Meng‐Ya Liu, Hong‐Bing Yao, Cheng Chen   +2 more
wiley   +1 more source