Results 21 to 30 of about 4,830,735 (205)

GATA3 haploinsufficiency causes a rapid deterioration of distortion product otoacoustic emissions (DPOAEs) in mice [PDF]

Neurobiology of Disease, 2005
Human HDR (hypoparathyroidism, deafness and renal dysplasia)-syndrome is caused by haploinsufficiency of zinc-finger transcription factor GATA3. The hearing loss due to GATA3 haploinsufficiency has been shown to be peripheral in origin, but it is unclear
M.A.J. van Looij, H. van der Burg, R.S. van der Giessen, M.M. de Ruiter, J. van der Wees, J.H. van Doorninck, C.I. De Zeeuw, G.A. van Zanten   +7 more
doaj   +2 more sources

CHD8-Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs. [PDF]

Adv Sci (Weinh)
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Huang Y, Hu Z, Liao J, Huang L, Liu J, Tu C, Li Y, Xie L, Bi S, Fang X, Chen J, Du L, Sun W, Wang H, Zhang S, Chen D, Tu Z.   +16 more
europepmc   +2 more sources

Gene of the month: GATA3 [PDF]

, 2023
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling.
Lloyd, K., Cumberbatch, M., Jubber, I., Griffin, J., Qiang, Z.   +4 more
core   +1 more source

Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear [PDF]

Journal of Comparative Neurology, 2001
AbstractThe transcription factors GATA3 and Pax2 are expressed throughout development of the mouse inner ear. We have used antibodies to study their temporal and spatial expression patterns from embryonic days E8–E16.5. The two factors show reciprocal relationships in the regional patterning of the early otocyst and cellular patterning within the ...
Grace, Lawoko-Kerali, Marcelo N, Rivolta, Matthew, Holley   +2 more
openaire   +2 more sources

The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4 [PDF]

Development, 1999
Abstract In this paper, we show that the transcription factor GATA3 is dynamically expressed during hindbrain development. Function of GATA3 in ventral rhombomere (r) 4 is dependent on functional GATA2, which in turn is under the control of Hoxb1.
I, Pata, M, Studer, J H, van Doorninck, J, Briscoe, S, Kuuse, J D, Engel, F, Grosveld, A, Karis   +7 more
openaire   +2 more sources

LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3 [PDF]

BMC Biology, 2014
Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such as the relatively common neonatal hypertrophic pyloric stenosis, and primary ...
Li, Yushan, Pan, Jirong, Wei, Chao, Chen, Juan, Liu, Ying, Liu, Jiali, Zhang, Xiaoxin, Evans, Sylvia M, Cui, Yan, Cui, Sheng   +9 more
openaire   +2 more sources

E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment [PDF]

Blood, 2013
Key Points GATA3 is elevated in E2A−/− DN2 cells. GATA3 contributes to arrested T-cell development from E2A−/− DN2 cells.
Wei, Xu, Tiffany, Carr, Kevin, Ramirez, Stephanie, McGregor, Mikael, Sigvardsson, Barbara L, Kee   +5 more
openaire   +2 more sources

An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation [PDF]

International Immunology, 2011
CD4 T(h) are critical for orchestrating adaptive immune responses. The expression of the transcription factor GATA3 (GATA-binding protein 3) is up-regulated or down-regulated during T(h)2 or T(h)1 cell differentiation, respectively. Furthermore, GATA3 is responsible for induction of T(h)2 differentiation and represses T(h)1 differentiation.
Ryoji, Yagi, Jinfang, Zhu, William E, Paul   +2 more
openaire   +2 more sources

GATA3 Transcription Factor Abrogates Smad4 Transcription Factor-mediated Fascin Overexpression, Invadopodium Formation, and Breast Cancer Cell Invasion [PDF]

Journal of Biological Chemistry, 2013
Transforming growth factor β (TGFβ) is a potent and context-dependent regulator of tumor progression. TGFβ promotes the lung metastasis of basal-like (but not the luminal-like) breast cancer. Here, we demonstrated that fascin, a pro-metastasis actin bundling protein, was a direct target of the canonical TGFβ-Smad4 signaling pathway in basal-like breast
Jianwei, Sun, Huifang, He, Smitha, Pillai, Yin, Xiong, Sridevi, Challa, Liyan, Xu, Srikumar, Chellappan, Shengyu, Yang   +7 more
openaire   +2 more sources

GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage [PDF]

, 2021
GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4+ T helper 2 (Th2) cells, but is also involved in a variety of processes such as immune regulation, proliferation and maintenance in other T cell and non-T cell ...
Elizabeth C. Carroll, Lisa E. L. Romano, Callender, LA, Henson, Sian M., Kelly, Audrey, Schroth, J, Akbar, Arne N., Carroll, EC, Johannes Schroth, J. Paul Chapple, Eleanor Hendy, Sian M. Henson, Paul Lavender, Carroll, Elizabeth C., Hendy, E, Schroth, Johannes, Lauren A. Callender, Chapple, JP, Lavender, P, Hendy, Eleanor, Garrod-Ketchley, Conor, Arne N. Akbar, Romano, Lisa E.L., Garrod-Ketchley, C, Akbar, AN, Audrey Kelly, Romano, LEL, Kelly, A, Chapple, J. Paul, Henson, SM, Conor Garrod-Ketchley, Henson, S, Callender, Lauren A., Lavender, Paul, Akbar, Arne N, Callender, Lauren A, Carroll, Elizabeth C, Romano, Lisa E L, Henson, Sian M, Chapple, J Paul   +39 more
core   +2 more sources