Results 231 to 240 of about 46,994 (248)

Allergen Responses Modified by a GATA3 DNAzyme

New England Journal of Medicine, 2015
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CARAMORI, Gaetano, Chung Kian F., Barnes Peter J.   +2 more
openaire   +6 more sources

Role of GATA3 in tumor diagnosis: A review

Pathology - Research and Practice, 2021
GATA binding protein 3 (GATA3) belongs to a family of transcription factors comprising six members. These proteins identify G-A-T-A containing sequences in the target gene and bind to DNA target via two zinc-finger domains. The aim of this study was to evaluate the role of GATA3 in the diagnosis of tumors and its value as a prognostic marker.
Mahdis, Khazaeli Najafabadi, Elham, Mirzaeian, Sahar, Memar Montazerin, Amir Reza, Tavangar, Mohammadreza, Tabary, Seyed Mohammad, Tavangar   +5 more
openaire   +2 more sources

GATA3 immunohistochemical expression in invasive urothelial carcinoma

Urologic Oncology: Seminars and Original Investigations, 2016
GATA binding protein 3 (GATA3) is a transcription factor, which belongs to a distinct family of tumor suppressor genes. It is involved in human cancer cell growth and differentiation, and plays an important role in cell proliferation and apoptosis. Although, its expression has been reported in various cancers, there are limited data in genitourinary ...
Kareem Hosny, Mohammed, Momin T, Siddiqui, Cynthia, Cohen   +2 more
openaire   +2 more sources

The role of Gata3 in renin cell identity

American Journal of Physiology-Renal Physiology, 2023
Gata3, a dual zinc-finger transcription factor, is responsible for the identity and localization of renin cells in the kidney. Mice with a conditional deletion of Gata3 in renin lineage cells have abnormal kidneys with juxtaglomerular cells that lose their characteristic location and are misplaced outside and around arterioles and glomeruli.
Jesus S. Neyra, Silvia Medrano, Alexandre De Goes Martini, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez   +4 more
openaire   +2 more sources

GATA3 immunohistochemical expression in urothelial carcinoma.

Journal of Clinical Oncology, 2016
e16135Background: GATA binding protein 3 (GATA3) is a transcription factor, which belongs to a distinct family of tumor suppressor genes.
Frederick Edem Doamekpor, AMR Mohamed, Momin Siddiqui, AlKhoder Ayman, Tengteng Wang, Khuram Ashraf, Omer Kucuk, Cynthia Cohen   +7 more
openaire   +1 more source

Aberrant GATA3 Staining in Prostatic Adenocarcinoma

American Journal of Surgical Pathology, 2020
Distinguishing between poorly differentiated urothelial carcinoma and high-grade prostatic adenocarcinoma is a common challenge in genitourinary pathology, particularly when the tumor involves the bladder neck or prostatic urethra. Clinically, the distinction between these 2 tumors can also be difficult.
Timothy M, McDonald, Jonathan I, Epstein
openaire   +2 more sources

GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms

The American Journal of Dermatopathology, 2017
Abstract:Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors ...
Joana, Pardal, Uma, Sundram, M Angelica, Selim, Mai P, Hoang   +3 more
openaire   +2 more sources

Immunohistochemical GATA3 expression in prostate adenocarcinoma: pitfalls

Journal of Immunoassay and Immunochemistry
Recent studies have reported aberrant GATA3 immunohistochemical expression in high-grade prostate carcinoma, raising concerns about its specificity. This study aimed to evaluate GATA3 immunohistochemical expression in prostate adenocarcinoma.We retrospectively collected cases of primary prostate adenocarcinoma diagnosed in our pathology department(2019-
Sarra, Ben Rejeb, Yasmine, Chaabane, Kalthoum, Dridi, Rym, Bahloul, Hassen, Khouni   +4 more
openaire   +2 more sources

Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes

Molecular Immunology, 2009
The zinc-finger transcription factors Gata3 and ThPOK have both been implicated in positive selection of double positive (DP) thymocytes towards the CD4 lineage. As in the absence of Gata3, expression of ThPOK is lacking, Gata3 may directly regulate ThPOK expression.
van Hamburg, Jan Piet, de Bruijn, Marjolein J W, Ribeiro de Almeida, Claudia, Dingjan, Gemma M, Hendriks, Rudi W   +4 more
openaire   +3 more sources