Results 131 to 140 of about 10,255 (168)

Predictive value of peripheral blood cell-free DNA breast cancer gene mutation profiling for postoperative pathological malignancy in BI-RADS 4 breast nodules. [PDF]

Front Genet
Lyu G, Duan H, Sheng X, Liu L, Luo J.
europepmc   +1 more source

Mesonephric-Like Adenocarcinoma of the Endometrium: A Rare and Diagnostically Challenging Entity. [PDF]

Cureus
Kirubahar A, Sundaram S, D D, Gunabooshanam B, Pv P.   +4 more
europepmc   +1 more source

EPHA2 and WNT reciprocally regulate MAPK-dependent gene expression in a pancreatic cancer model. [PDF]

JCI Insight
Wadia SR, Hu C, Patnaik S, Sridharan S, Daly RJ, Virshup DM, Madan B.   +6 more
europepmc   +1 more source

Cancer-Specific Mutation of GATA3 Disrupts the Transcriptional Regulatory Network Governed by Estrogen Receptor Alpha, FOXA1 and GATA3 [PDF]

Nucleic Acids Research, 2020
Abstract Estrogen receptors (ER) are activated by the steroid hormone 17β-estradiol. Estrogen receptor alpha (ER-α) forms a regulatory network in mammary epithelial cells and in breast cancer with the transcription factors FOXA1 and GATA3.
Bony De Kumar, Brian Bennett, Paul A Wade   +2 more
exaly   +3 more sources

Mutation of GATA3 in Human Breast Tumors [PDF]

Oncogene, 2004
GATA3 is an essential transcription factor that was first identified as a regulator of immune cell function. In recent microarray analyses of human breast tumors, both normal breast luminal epithelium and estrogen receptor (ESR1)-positive tumors showed high expression of GATA3.
Charles M. Perou, Stephen Chanock, Anita Langerød   +2 more
exaly   +3 more sources

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Genomic characterization of the GATA3 mutational landscape in breast cancer.

Journal of Clinical Oncology, 2023
1039 Background: GATA3 expression is broadly used as a biomarker for diagnosing cancer of breast origin and its expression is strongly associated with estrogen receptor (ER)-positive luminal phenotype. Although GATA3 mutations are observed in 12-18% of breast cancers (BC), they are poorly characterized.
Jason A Mouabbi, Funda Meric-Bernstam, Polina Turova, Konstantin Chernyshov, Vladimir Kushnarev, Nikita Kotlov, Jessica H. Brown, Patrick Clayton, Krystle Nomie, Nathan Fowler, Debu Tripathy, Senthil Damodaran   +11 more
openaire   +1 more source

The Significance and Therapeutic Potential of GATA3 Expression and Mutation in Breast Cancer: A Systematic Review

Medicinal Research Reviews, 2015
AbstractGATA3 is a critical transcription factor in the development of various human systems. The notion that GATA3 expression is required for the differentiation and maintenance of normal breast tissue has been well established. Recently, GATA3 is found to actively participate in the multistep process leading breast cancer pathogenesis, including ...
Binghe Xu, Zitong Zhao, Jiuda Zhao
exaly   +3 more sources

A Missense GATA3 Mutation, Thr272Ile, Causes the Hypoparathyroidism, Deafness, and Renal Dysplasia Syndrome [PDF]

Journal of Clinical Endocrinology and Metabolism, 2009
Context: The hypoparathyroidism, deafness, renal dysplasia (HDR) syndrome is caused by mutations in the gene encoding GATA3, which belongs to a family of dual zinc-finger transcription factors that have a role in vertebrate embryonic development.Objective: The aim of the study was to identify the GATA3 mutation in a HDR patient and determine its ...
Rajesh Thakker, Irina V Grigorieva, Treena Cranston   +2 more
exaly   +3 more sources