Results 41 to 50 of about 1,580,633 (289)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Field effect transistor and method of construction thereof [PDF]
, 1978 A field effect transistor is constructed by placing a semi-conductor layer on an insulating substrate so that the gate region is separated from source and drain regions. The gate electrode and gate region of the layer are of generally reduced length, the
Fletner, W. R.
core +1 more source
, 2013 We present a quantum SWAP gate valid for quantum systems of an arbitrary dimension. The gate generalizes the CNOT implementation of the SWAP gate for qubits and keeps its most important properties, like symmetry and simplicity.
Chamorro-Posada, Pedro +1 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
, 2010 We present transport measurements of a tunable silicon metal-oxide-semiconductor double quantum dot device with lateral geometry. Experimentally extracted gate-to-dot capacitances show that the device is largely symmetric under the gate voltages applied.
C. Borrás Pinilla +13 more
core +1 more source
Electrostatic confinement of electrons in graphene nano-ribbons [PDF]
, 2009 Coulomb blockade is observed in a graphene nanoribbon device with a top gate. When two pn junctions are formed via the back gate and the local top gate, electrons are confined between the pn junctions which act as the barriers.
Alberto F. Morpurgo +4 more
core +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
SITUS BESOLE: SISA-SISA PINTU GERBANG DARI MASA KADIRI
Berkala Arkeologi, 2009 Besole is a site wher remants of a brick gateway were found. This site is assumed to be dated from Kadiri Kingdom period (1041 AD – 1222 AD), though it exists in Blitar district. The gateway is an important element in a building complex or a city.
Kuswanto Kuswanto
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Optimal simulation of three-qubit gates [PDF]
, 2013 In this paper, we study the optimal simulation of three-qubit unitary by using two-qubit gates. First, we give a lower bound on the two-qubit gates cost of simulating a multi-qubit gate.
Ying, Mingsheng, Yu, Nengkun
core