Results 51 to 60 of about 1,580,633 (289)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Performance Measurements of a Theoretical Positron Emission Tomography Scanner Model “T2PET-NSBD” Dedicated to Plant Imaging using Monte Carlo Simulations [PDF]

E3S Web of Conferences
This work focuses on the performance measurement of a theoretical scanner with an extended Axial FOV for plant Imaging, which is based on the block detector of Naviscan PEM Flex Solo II scanners using the Geant4 Application for Tomographic Emission (GATE)
Youbi Issam, Saaidi Rahal, El Bardouni Tarek, El Hajjaji Otman   +3 more
doaj   +1 more source

Carbon Radiotheraphy For Head and Neck Cancer: Dosimetric Comparison with Photon Plans

Cumhuriyet Science Journal, 2022
Radiation therapy is one of the most widely used treatment methods for tumors. The therapeutic use of carbon ions is more advantageous than other radiotherapy techniquies especially photon-based irradiation due to its physical properties and ...
Deniz Erkal, Sinan Kuday
doaj   +1 more source

Bivariate Beta-LSTM

, 2019
Long Short-Term Memory (LSTM) infers the long term dependency through a cell state maintained by the input and the forget gate structures, which models a gate output as a value in [0,1] through a sigmoid function.
Jang, JoonHo, Moon, Il-Chul, Shin, Seung jae, Song, Kyungwoo   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On a generalized quantum SWAP gate [PDF]

, 2012
The SWAP gate plays a central role in network designs for qubit quantum computation. However, there has been a view to generalize qubit quantum computing to higher dimensional quantum systems. In this paper we construct a generalized SWAP gate using only
COLIN M. WILMOTT, Fowler A. G., PETER R. WILD, Rosen K. H.   +3 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Effects of Spinal Decompression and Segmental Spinal Instrumentation on Lower Limb Functionality in Patients with Spinal Osteoarthritis

Life
Spinal osteoarthritis, a degenerative condition of the spine, significantly impairs quality of life, causing pain, stiffness, and limited mobility. Treatment primarily aims to improve functionality and quality of life. This study investigated the effects
Milan Mirković, Filip Kukić, Dragan Mirkov, Dejan Marinković, Lazar Mičeta, Sanja Mirković, Biljana Božić Nedeljković, Zoran Baščarević   +7 more
doaj   +1 more source

Supercurrent switching in Three- and Four- Terminal Josephson Junctions

, 1998
Control of the Josephson current by varying a gate current has recently been demonstrated in both 4-terminal and 3-terminal junctions. We show that, when the the gates are weakly coupled to the Josephson junction, the Josephson current versus gate ...
Bagwell, Philip F., Ilhan, H. Tolga
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source