Results 101 to 110 of about 1,212,232 (342)

Gating machinery of InsP3R channels revealed by electron cryomicroscopy

Nature, 2015
Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are ubiquitous ion channels responsible for cytosolic Ca2+ signalling and essential for a broad array of cellular processes ranging from contraction to secretion, and from proliferation to cell death ...
G. Fan, Matthew L. Baker, Zhao Wang, M. R. Baker, P. Sinyagovskiy, W. Chiu, S. Ludtke, I. Serysheva   +7 more
semanticscholar   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Tecniche di Breath - Hold a confronto nel trattamento del carcinoma mammario

Journal of Biomedical Practitioners, 2018
Nella radioterapia del carcinoma mammario sinistro la dose erogata all’arteria discendente anteriore (DA) aumenta il rischio di sviluppare un infarto del miocardio.
Corrado Macauda, Erminia Infusino, Davide Miccolis, Angelo Montagnoli, Claudio Dionisi   +4 more
doaj   +1 more source

Spin gating electrical current

, 2012
We use an aluminium single electron transistor with a magnetic gate to directly quantify the chemical potential anisotropy of GaMnAs materials. Uniaxial and cubic contributions to the chemical potential anisotropy are determined from field rotation ...
Campion, R. P., Ciccarelli, C., Ferguson, A. J., Gallagher, B. L., Irvine, A. C., Jungwirth, T., Wunderlich, J., Zarbo, L. P.   +7 more
core   +1 more source

Frontostriatal Gating of Tinnitus and Chronic Pain

Trends in Cognitive Sciences, 2015
Tinnitus and chronic pain are sensory-perceptual disorders associated with negative affect and high impact on well-being and behavior. It is now becoming increasingly clear that higher cognitive and affective brain systems are critically involved in the ...
J. Rauschecker, E. S. May, A. Maudoux, M. Ploner   +3 more
semanticscholar   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Cell Reports, 2018
Summary: Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms ...
Wang Zheng, Ruiqi Cai, Laura Hofmann, Vasyl Nesin, Qiaolin Hu, Wentong Long, Mohammad Fatehi, Xiong Liu, Shaimaa Hussein, Tim Kong, Jingru Li, Peter E. Light, Jingfeng Tang, Veit Flockerzi, Leonidas Tsiokas, Xing-Zhen Chen   +15 more
doaj   +1 more source

Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels

, 2007
The hair cell's mechanoreceptive organelle, the hair bundle, is highly sensitive because its transduction channels open over a very narrow range of displacements.
A J Hudspeth, AC Crawford, AJ Hudspeth, AJ Hudspeth, AJ Hudspeth, Andrei S Kozlov, J Howard, J Silber, JA Assad, JH Nam, KD Karavitaki, KH Iwasa, M Nowak, ME Bashtanov, P Martin, P Martin, R Fettiplace, RA Jacobs, RE Marquis, S Henderson, Thomas Risler, W Denk, W Denk, W Denk, W Denk   +24 more
core   +4 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Electrostatic gating and intercalation in 2D materials

Nature Reviews Materials, 2022
Yecun Wu, Danfeng Li, Chun-Lan Wu, H. Hwang, Yi Cui   +4 more
semanticscholar   +1 more source